Using real-time uncoating
measurements and high-resolution structures, a research team comprised of docent Varpu Marjomaki's group (Nanoscience Center at the University of Jyvaskyla) and professor Sarah Butcher's group (University of Helsinki) found that the common molecule in serum and interstitial fluids, albumin, and an ion composition that is typically developed in cellular vesicles, trigger expansion of the virion.
AB-423 exhibits a dual mode of action in C3AhNTCP cells, namely inhibition of encapsidation of pgRNA during ongoing infection in addition to inhibition of rcDNA-cccDNA synthesis, presumably via inhibition of the capsid uncoating
Several receptors associated with virus binding, internalization, and uncoating
have been identified .
revealed that HD-5 blocked the uncoating
mechanism of the virus by stabilizing the capsid in BrdU-labeled HAdV-5 .
From there, the capsid disassembles through a process called "uncoating
," which is crucial to the synthesis of viral DNA from its RNA genome and the hijacking of the cell's functions.
Lou et al., "Recruitment of endophilin to clathrin-coated pit necks is required for efficient vesicle uncoating
after fission," Neuron, vol.
The process of uncoating
mtDNA has not been elucidated but likely involves the selective and processive dissociation of TFAM .
Maoto Inhibits Endosomal Acidification and Uncoating
of Influenza Virus.
Receptor-mediated endocytosis is a prerequisite for fusion and uncoating
of all known Flaviviridae family members.
As coat protein gene of PVX interferes with viral uncoating
, movement and translation (Fedorkin et al., 2001) thus a transgenic plant harboring resistance against CP gene, will be potentially more effective against invading PVX.