Also found in: Thesaurus, Medical, Legal, Encyclopedia, Wikipedia.


v. un·cou·pled, un·cou·pling, un·cou·ples
1. To disconnect: uncouple railroad cars.
2. To set loose or release from a couple.
To come or break loose.

un·cou′pler n.


(Biochemistry) biochem an agent responsible for the uncoupling of oxidative phosphorylation
References in periodicals archive ?
The inhibitors were added in the following order: oligomycin (3 [micro]M) (Sigma), to inhibit complex V (to assess nonmitochondrial respiratory capacity or proton LEAK rate), carbonyl cyanide-p-trifluoro-methoxyphenylhydrazone (FCCP) (Sigma) uncoupler with stepwise titration in 0.
am says she's a "freaking phenomenal" singer (as well as actress, healthy eater, conscious uncoupler etc).
Although in literature, the mode of action of phosphine has been mentioned as uncoupler of oxidative phosphorylation in electron transport chain but this study was specifically planned to evaluate the direct/indirect effect of phosphine on various esterase levels to correlate its activities with development of tolerance in T.
4 Bracket Outer, Uncoupler As Per Abb Drg No-Ia-021-0164, Alt-1 Or Latest Qty.
Although initially suggested as PKC[delta] inhibitor, lately it was revealed that rottlerin is a mitochondrial uncoupler as it depolarizes the mitochondrial membrane potential and reduces cellular ATP levels.
Increase Fatty acid oxidation: Peripheral application of Adiponectin attenuated body weight gain and decreased visceral adipocity by increasing the expression of Uncoupler protein 1, 2, 3.
Salicylic acids is an uncoupler and inhibitor of mitochondrial electron transport.
Thirty six technical-grade insecticides were used for bioassays representing 8 IRAC mode of action groups or subgroups with alphanumeric designations in parentheeses as follows; 7 acteylcholine inhibitors (1B)--organophosphates, 7 acteylcholine inhibitors (1A)--carbamates, 12 sodium channel modulators (3A)--pyrethroids, 6 nicotinic acetylcholine receptor agonists (4A) - neonicotinoids, 1 nicotinic acetyl choline receptor allosteric activator (5)--spinosyn, chloride channel activator (6)--avermectin, 1 oxidative phosphorylation uncoupler (13) -chlorfenpyr, and 1 GABA-gated chloride channel antagonist (2B) phenylpyrazole (fiprol).
A characteristic feature of the complex V-deficient cells was the clear stimulation of oxygen consumption by addition of an uncoupler [2 [micro]mol/L carbonyl cyanide 3-chlorophenyl hydrazone (CCCP)] (Fig.
Mitochondrial uncoupling protein (UCP) mediated proton conductance was measured as increased fatty acid-induced respiration, which was then compared to maximum respiration induced by the chemical uncoupler carbonylcyanide-p-trifluoromethoxyphenylhydrazone (FCCP).
A rapid increase in cell-associated ciprofloxacin uptake among isolates belonging to the genosubtypes was evident after addition of carbonyl cyanide m-chlorophenylhydrazone (CCCP), a proton motive force uncoupler.