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v. un·cou·pled, un·cou·pling, un·cou·ples
1. To disconnect: uncouple railroad cars.
2. To set loose or release from a couple.
To come or break loose.

un·cou′pler n.


(Biochemistry) biochem an agent responsible for the uncoupling of oxidative phosphorylation
References in periodicals archive ?
Gap junction uncoupler heptanol prevents cell-to-cell progression of hypercontracture and limits necrosis during myocardial reperfusion.
The mitochondrial uncoupler 2,4-dinitrophenol attenuates tissue damage and improves mitochondrial homeostasis following transient focal cerebral ischemia.
A simple titration protocol was used, including (1) ROUTINE respiration of intact cells (R,2) noncoupled respiration induced by optimum concentrations of the uncoupler carbonyl cyanide m-chlorophenyl hydrazone (CCCP) corresponding to electron transfer capacity (E), and (3) antimycin A-inhibitied respiration corresponding to residual oxygen consumption (Rox).
When TA is absorbed into the circulatory system, which can use as an uncoupler of oxidation and phosphorylation, resulting in increasing of oxygen consumption (Singleton and Kratzer, 1969).
Uncoupling protein 2 (UCP2), which is widely expressed in human tissues and serves as an uncoupler of oxidative phosphorylation, is involved in the regulation of glucolipid metabolism and ATP production [1, 2].
OCR measurements revealed that application of LPS at a dose that declined FAO (25 [micro]g/ml) already after 2.5 h of incubation led to the reduction of [OCR.sub.max] in the presence of the uncoupler FCCP (Figures 3(a) and 3(b)) indicating decreased mitochondrial effectiveness in the presence of LPS.
As if Gwyneth Paltrow wasn't annoying enough, will.i.am says she's a "freaking phenomenal" singer (as well as actress, healthy eater, conscious uncoupler etc).
Perhaps more promising would be to search for such signals in a Langendorff-perfused heart with an electromechanical uncoupler to eliminate contractions.
Bouillaud, "UCP2, not a physiologically relevant uncoupler but a glucose sparing switch impacting ROS production and glucose sensing," Biochimica et Biophysica Acta (BBA)-Bioenergetics, vol.
In this study, we submitted bovine epididymal spermatozoa to treatment with the oxidative phosphorylation uncoupler carbonyl cyanide 4-(trifluoromethoxy)phenylhydrazone (FCCP) to significantly reduce mitochondrial ATP synthesis and stimulated the glycolytic pathway by glucose addition.
CCCP is a known mitochondrial uncoupler that allows proton transportation to the mitochondrial matrix, causing mitochondrial trans-membrane potential depolarization [21].