Gap junction uncoupler
heptanol prevents cell-to-cell progression of hypercontracture and limits necrosis during myocardial reperfusion.
The mitochondrial uncoupler
2,4-dinitrophenol attenuates tissue damage and improves mitochondrial homeostasis following transient focal cerebral ischemia.
A simple titration protocol was used, including (1) ROUTINE respiration of intact cells (R,2) noncoupled respiration induced by optimum concentrations of the uncoupler
carbonyl cyanide m-chlorophenyl hydrazone (CCCP) corresponding to electron transfer capacity (E), and (3) antimycin A-inhibitied respiration corresponding to residual oxygen consumption (Rox).
When TA is absorbed into the circulatory system, which can use as an uncoupler
of oxidation and phosphorylation, resulting in increasing of oxygen consumption (Singleton and Kratzer, 1969).
Uncoupling protein 2 (UCP2), which is widely expressed in human tissues and serves as an uncoupler
of oxidative phosphorylation, is involved in the regulation of glucolipid metabolism and ATP production [1, 2].
OCR measurements revealed that application of LPS at a dose that declined FAO (25 [micro]g/ml) already after 2.5 h of incubation led to the reduction of [OCR.sub.max] in the presence of the uncoupler
FCCP (Figures 3(a) and 3(b)) indicating decreased mitochondrial effectiveness in the presence of LPS.
As if Gwyneth Paltrow wasn't annoying enough, will.i.am says she's a "freaking phenomenal" singer (as well as actress, healthy eater, conscious uncoupler
Perhaps more promising would be to search for such signals in a Langendorff-perfused heart with an electromechanical uncoupler
to eliminate contractions.
Bouillaud, "UCP2, not a physiologically relevant uncoupler
but a glucose sparing switch impacting ROS production and glucose sensing," Biochimica et Biophysica Acta (BBA)-Bioenergetics, vol.
In this study, we submitted bovine epididymal spermatozoa to treatment with the oxidative phosphorylation uncoupler
carbonyl cyanide 4-(trifluoromethoxy)phenylhydrazone (FCCP) to significantly reduce mitochondrial ATP synthesis and stimulated the glycolytic pathway by glucose addition.
CCCP is a known mitochondrial uncoupler
that allows proton transportation to the mitochondrial matrix, causing mitochondrial trans-membrane potential depolarization .