CMP-001 is designed to activate innate immunity to convert "uninflamed
" tumors, which generally do not respond to anti-PD-1/L1 therapy, into "inflamed" tumors, which are responsive to PD-1 inhibition.
Demonstration of functional role of TECK/CCL25 in T lymphocyte-endothelium interaction in inflamed and uninflamed
Fluoroquinolones are the most commonly used first-line oral antimicrobials for the treatment of CBP due to their superior penetration into uninflamed
prostatic fluids or secretions (10-50% of serum concentrations) [2, 14, 15].
Histologically, the analyzed biopsy contained newly formed bone, residual grafting material, and vascularized uninflamed
Fellow eyes also had abnormalities of the tear film function, and nearly 50% of these eyes had uninflamed
pinguecula (40%) or pterygium (9%).
In the case of the control group, samples were taken from random colon sections; samples from colitis-induced animals were taken from inflamed colon region as well as from nonadjacent uninflamed
Histological examination of tissues had revealed characteristic finger-like projections of tissue lined by an increased number of squamous cells and by the uninflamed
fibrovascular core containing small blood vessels with conserved cellular orientation and normal differentiation without signs of cytological atypia (Figure 2).
(35) However, CCR10 is largely absent from the T cells in uninflamed
skin; (33,36) hence, the CCL17/CCR10 axis appears to be important for T cell migration into inflamed skin but not for the constitutive T cell migration into normal skin.
TSPO PET imaging appears to be a promising approach to follow early events in the pathophysiology of RA, suggesting that a precocity medical care should be feasible even before the structural alterations, especially as the uninflamed
knee joints of RA patients showed a significant greater TSPO tracer uptake than in healthy controls .
Even though skin and oral mucosae are continuously in contact with commensal and opportunistic microorganisms, they generally remain healthy and uninflamed
. Host defense peptides (HDPs) make up the body's first line of defense against many invading pathogens, including bacteria, fungi, and viruses.
 described a distinctive pattern of TLR expression profile of DPSCs in uninflamed
and inflamed conditions.
In human colonic biopsies from IBD patients, WISP1 relative expression was found to be markedly increased in inflamed colons compared with uninflamed