"We were particularly encouraged by the finding that reconstitution of CD4+ T cells with NiCord treatment was at least as fast as transplant with unmanipulated
cord blood and unrelated bone marrow in adolescents and young adults, who typically achieve more rapid recovery than adults." said Jaap-Jan Boelens of Memorial Sloan Kettering Cancer Center.
These data were compared to cohorts of adolescent and young adults with hematologic malignancies receiving unmanipulated
cord blood transplantation or unrelated bone marrow transplantation.
In concert with the treatment exposures, we exposed randomly selected batches of larvae to "unmanipulated
control" conditions, where we poured the contents of the 125-mL beakers into finger bowls, as described above, and then immediately subjected them to settlement assays.
Hence, the present study investigated the association of cell compositions in allografts with outcomes after unmanipulated
haploidentical SCT (haplo-SCT) for patients with acquired severe aplastic anemia (SAA).
Therefore, they were unmanipulated
and occurred naturally without interference.
Similar incidence of severe acute GVHD and less severe chronic GVHD in PBSCT from unmanipulated
, haploidentical donors compared with that from matched sibling donors for patients with haematological malignancies.
Olivieri et al., "A modified posttransplant cyclophosphamide regimen, for unmanipulated
haploidentical marrow transplantation, in acute myeloid leukemia: a multicenter study," Biology of Blood and Marrow Transplantation, vol.
A comparison between alloge neic stem cell transplantation from unmanipulated
haploidentical and unrelated donors in acute leukemia.
The medium-format photos are unmanipulated
and void of the accoutrements that might denote class or social status.
Once the negatives were clean, each was scanned at high resolution to produce unmanipulated
'archival' scans to record each negative.
In our center, we established an unmanipulated
haploidentical blood and marrow transplantation (HBMT) protocol that has a lower incidence of graft failure compared to other haploidentical transplant modalities , but PT still significantly increases the risk of transplant-related mortality (TRM) [4-6, 8].
Image fluorescence intensity was measured by Zen software (Carl Zeiss, Gottingen, Germany) on the captured unmanipulated