uracil


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u·ra·cil

 (yo͝or′ə-sĭl)
n. Abbr. U
A pyrimidine base, C4H4N2O2, that is an essential constituent of RNA.

[ur(ea) + ac(etic) + -il, substance relating to.]

uracil

(ˈjʊərəsɪl)
n
(Biochemistry) biochem a pyrimidine present in all living cells, usually in a combined form, as in RNA. Formula: C4H4N2O2
[C20: from uro-1 + acetic + -ile]

u•ra•cil

(ˈyʊər ə sɪl)

n.
a pyrimidine base, C4H4N2O2, that is one of the fundamental components of RNA, in which it forms base pairs with adenine. Symbol: U
[1905–10; ur-1 + ac (etic) + -il, of uncertain orig.]

u·ra·cil

(yo͝or′ə-sĭl)
A base that is a component of RNA, forming a base pair with adenine during transcription.
ThesaurusAntonymsRelated WordsSynonymsLegend:
Noun1.uracil - a base containing nitrogen that is found in RNA (but not in DNA) and derived from pyrimidine; pairs with adenine
ribonucleic acid, RNA - (biochemistry) a long linear polymer of nucleotides found in the nucleus but mainly in the cytoplasm of a cell where it is associated with microsomes; it transmits genetic information from DNA to the cytoplasm and controls certain chemical processes in the cell; "ribonucleic acid is the genetic material of some viruses"
nucleotide, base - a phosphoric ester of a nucleoside; the basic structural unit of nucleic acids (DNA or RNA)
Translations
uracile
References in periodicals archive ?
They describe in the June 29 Nature an "efficient prebiotic route" for the synthesis of cytosine and uracil.
The two contend that primordial RNA would have contained HMU at many sites where modern RNA has uracil.
The IS mixture was prepared in water containing 1 mmol/L each of stable-isotope-labeled N-carbamyl-aspartate (N-C-aspartate), dihydroorotate, orotate, orotidine, uridine, and uracil.
In humans, the pathway for the catabolism of uracil and thymine consists of three consecutive steps.
VioQuest's oncology portfolio includes: Xyfid[TM] (1% uracil topical), for the treatment and prevention of Hand-Foot Syndrome, a common side effect from certain chemotherapy treatments, and to treat dry skin conditions and manage the burning and itching associated with various dermatoses; VQD-002 (triciribine phosphate monohydrate), a targeted inhibitor of Akt activation; and Lenocta[TM] (sodium stibogluconate), an inhibitor of certain protein tyrosine phosphatases such as SHP-1, SHP-2, and PTP1B.
Among these were hippuric acid, homovanillic acid, uracil, 5-fluorouracil, and tryptophan.
We treated 15 [micro]L of purified PCR products (performed with 200 [micro]M dATP, dCTP, and dGTP; 160 [micro]M dTTP; and 40 [micro]M dUTP) with 1 U of uracil N-glycosylase (Epicentre Technologies) and 1 U of shrimp alkaline phosphatase (Amersham Biosciences).
PSI-7977 is a prodrug of a uracil nucleotide analog polymerase inhibitor we are developing for the treatment of chronic HCV infection.
The general amplification conditions were an initial incubation step of 2 min at 50 [degrees]C to allow uracil DNA glycosylase-mediated elimination of exogenous PCR product contamination (14) and an enzyme heat activation step of 5 min at 95 [degrees]C, followed by 35 cycles of 30 s at 95 [degrees]C for denaturation and 1 min at 60 [degrees]C for annealing and extension.
VioQuest's oncology portfolio includes: Xyfid[TM] (1% uracil topical), for the treatment and prevention of Hand-Foot Syndrome, a common side effect associated with certain chemotherapy treatments, and to treat dry skin conditions and manage the burning and itching associated with various dermatoses; VQD-002 (triciribine phosphate monohydrate), a targeted inhibitor of Akt activation; and Lenocta[TM] (sodium stibogluconate), an inhibitor of certain protein tyrosine phosphatases such as SHP-1, SHP-2, and PTP1B.
PSI-7977, a uracil nucleotide analogue polymerase inhibitor of HCV, is being studied in multiple phase 2 trials.
The thermal profile used for the GAPDH method was as follows: before reverse transcription, the reaction was initiated at 50 [degrees]C for 2 min in the presence of uracil N-glycosylase, followed by a reverse transcription step at 60 [degrees]C for 30 min.