SEL-212 is a combination product candidate designed to sustain control of serum uric acid levels in patients with chronic refractory gout, potentially reducing harmful tissue urate
deposits which when left untreated can lead to debilitating gout flares and joint deformity.
The most commonly used dose of allopurinol, 300 mg/day, is insufficient to achieve the currently recommended serum urate
(sU) target of < 6.0 mg/dL in a large proportion of patients.
Gout is caused by a buildup of uric acid that forms urate
The small sample obtained showed abundant cholesterol crystals (Figure la, compensated polarized light), but a careful examination allowed identifying typical acicular crystals with a strong negative birefringence characteristic of monosodium urate
(Figure 1 b, black arrow, -A shows the compensator axis), confirming the diagnosis of gout.
(3-5) The pathophysiological mechanisms of AH involve overproduction of urate
, inefficient urate
excretion by kidneys, or both.
CHICAGO -- Failure to reach the therapeutic target of a serum urate
level below 6 mg/dL in gout patients is an independent risk factor for all-cause mortality conferring a 139% increased risk, Fernando Perez-Ruiz, MD, PhD, said at the annual meeting of the American College of Rheumatology.
In addition to the joint damage, urate
crystals can also deposit in other organs of the body, and if left unmanaged, gout can lead to significant tissue damage.
11, 2018 (HealthDay News) -- Diet explains little of the variation in serum urate
levels in the general population, while genetic factors make a greater contribution, according to a meta-analysis published online Oct.
Gout is caused by persistently elevated levels of urate
in the blood, which causes severe joint pain and swelling, especially in peoples' toes, knees, elbows, wrists and fingers.
This study indicates that even for people who have only had one or two prior gout flares, urate-lowering therapy to reduce serum urate
below 6 mg/dl may have benefit in reducing future flares.
Gout is the most common form of inflammatory arthritis, caused by the buildup of urate
crystals in a joint.
Hyperuricemia is characterized by an elevated serum urate
(>6-7 mg/dL) and has been found to be an increasing problem among Filipinos and elsewhere in the world.