uricase

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Related to urate oxidase: uricase, allopurinol

uricase

(ˈjʊərɪˌkeɪz)
n
(Biology) an enzyme found in organisms from bacteria to mammals but absent in humans
Collins English Dictionary – Complete and Unabridged, 12th Edition 2014 © HarperCollins Publishers 1991, 1994, 1998, 2000, 2003, 2006, 2007, 2009, 2011, 2014
References in periodicals archive ?
Urate oxidase, or uricase, is an enzyme present in most mammals that oxidizes uric acid to the water-soluble and readily excreted metabolite allantoin.
Also, looking good in phase II clinical trials for long-term urate lowering to prevent recurrent attacks of gout is a pegylated form of urate oxidase, Dr.
Also, looking good in phase II clinical trials for long-term urate lowering to prevent recurrent attacks of gout is a pegy-lated form of urate oxidase. Thomas Bardin, M.D., noted at the annual European congress of rheumatology.
ALLN-346 is an orally administered, novel urate oxidase that has been optimized for stability in the gastrointestinal tract.
Serum uric acid concentrations in the hyperuricemic mice (HU group) at 1 h after intraperitoneal injection of potassiumoxonate, a urate oxidase inhibitor, were significantly higher than those in normal mice, indicating that the mouse model of hyperuricemia was successfully established, consistent with a previous report [17].
Control of hyperuricemia in subjects with refractory gout, and induction of antibody against poly(ethylene glycol) (PEG), in a phase I trial of subcutaneous PEGylated urate oxidase. Arthritis Res Ther.