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studied QOL in patients on hemodialysis having uremic pruritus (UP).
The company is pursuing two conditions for clinical development: prurigo nodularis and uremic pruritus.
One such agent is nalfurafine, an oral kappa-opioid receptor agonist marketed in Japan for treatment of uremic pruritus in patients with chronic kidney disease undergoing hemodialysis and for refractory pruritus in chronic liver disease.
Objectives: Uremic pruritus is a common problem in hemodialysis patients.
Biopharmaceutical company Cara Therapeutics (NasdaqGM:CARA) said on Tuesday that it has closed enrolment under its Phase 2 proof-of-concept trial of CR845 for the treatment of uremic pruritus (UP), a chronic systemic itch condition that can occur in patients with renal failure and is often seen in patients receiving hemodialysis.
The pathogenesis of uremic pruritus, however, is poorly understood.
8 million and the firm also contrives to utilise the funds for the initiation of pivotal trials in two severe itch conditions: uremic pruritus and prurigo nodularis.
The most common skin changes were xerosis (98%), nail changes (93%), melanocytic nevus (78%), seborrheic keratosis (54%), pigmentation changes (51%), uremic pruritus (49%), tinea pedis (34%), actinic keratosis (23%), skin tags (16%), onychomycosis (17%), lentigo (16%), and cherry angioma (11%).
TRK-820, a highly selective κ (kappa) opioid receptor agonist, was initially launched in March 2009 in Japan as a treatment for hemodialysis-related uremic pruritus.
Evaluation of uremic pruritus at an outpatient hemodialysis unit.
A recent study by Chou (2000) examined the effect parathyroidectomy (N = 37) had on uremic pruritus and found that the best indicator was the level of calcium and phosphate product (Ca X P).
Company is focused on developing T111 for uremic pruritus and other itching conditions