Increased activity of the pudendal nerve is believed to increase contractions of the urethral sphincter
at the opening of the bladder, thereby helping to prevent accidental urine leakage.
6] In addition, several studies have reported that TOT procedures perform poorly when compared to RPMUS in patients with intrinsic urethral sphincter
deficiency (ISD) (defined by low urethral pressures).
5] guidelines both recommend urodynamics for complicated patients, to demonstrate incontinence (mobility, intrinsic urethral sphincter
deficiency), assess compliance/capacity, and rule out obstruction/voiding dysfunction.
The device pumps sterile saline slowly into the urethra, building pressure against the urethral sphincter
, and records the pressure required to achieve and maintain an open sphincter.
In GERD, the objective of such a treatment is to repair the esophageal sphincter, and in SUI to augment the urethral sphincter
To avoid damage to the external urethral sphincter
, the surgeon tends to limit the extent of the iceball near this structure at the apex and consequently the apex is a common site of recurrent cancer (51.
Duloxetine, by inhibiting this reuptake in the sacral spinal cord, increases neurotransmitter concentration resulting in increased activity of the nerve that in turn stimulates the external urethral sphincter
patent for its product for treating this condition, which is most commonly caused by the loss of tone or control of the smooth muscles surrounding the neck of the bladder or the urethral sphincter
These signals cause the muscles of the bladder and urethral sphincter
Stress urinary incontinence (SUI) is the most common type of incontinence and is caused by failure of the urethral sphincter
to prevent urine flow, particularly associated with physical activity.
There is one urethral bulking agent currently approved by the FDA for treatment of a subclass of SUI in which the urethral sphincter
is unable to close.
This disorder results in the involuntary loss of urine caused by the descending of the urethra and bladder (Type I) and/or loss of muscle tone to the urethral sphincter