'We are also pleased that the COMPARE trial continues to actively enroll patients, and we look forward to differentiating SEL-212 compared to the current FDA-approved uricase
therapy in adult patients with chronic refractory gout.
Uric acid + H20 Uricase
Allantoin + H2O H2O2 + Phenolic chromogens Peroxidase Red coloured compound.
based methods for determination of uric acid in serum.
A high throughput method for serum uric acid (SUA) detection based on the production of H2O2 by SUA and immobilized uricase
and the CL reaction was catalyzed by mesoporous metal oxide NPs .
Patients in the ongoing Phase 2 trial of SEL-212, designed to be the first non-immunogenic version of uricase
, received three monthly doses of up to 0.15 mg/kg of SVP Rapamycin with 0.2 or 0.4 mg/kg of pegsiticase, followed by two monthly doses of pegsiticase alone.
The alternative of high sensitivity, rapid and portable enzymatic biosensor kit is also expensive due to the cost of pure uricase
(Attala et al., 2009).
based methods for determination of uric acid in serum," Microchimica Acta, vol.
This metabolic shift represents the explanation of significant prevalence in bacterial types processing urease, uricase
, and indole and p-cresol forming enzymes .
The levels were determined by ultrasound enzyme (uricase
) PAP chromatography with COBAS (Roche diagnostic, Switzerland).
(ii) Uric acid ([micro]mol/L) was determined by the direct enzymatic method  in which uric acid was oxidized by uricase
coupled with peroxidase, and the results were measured colorimetrically.
Louis, MO, USA): fed standard commercial diet and water and receiving the uricase
inhibitor OA by intragastric gavage (750 mg/kg BW, daily) [9, 10]; and (d) fructose and oxonic acid group (FOA): fed control diet plus 10% (w/v) fructose in drinking water and receiving also the oxonic acid by intragastric gavage (750 mg/kg BW, daily), during the entire period.
Serum urea was assayed by urease enzyme, creatinine by Jaffe's kinetic method and uric acid by uricase