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1. A membrane-bound organelle in the cytoplasm of most cells, especially plant cells, containing water and dissolved substances such as salts, sugars, enzymes, and amino acids.
2. A small extracellular cavity or space within tissues.

[French, from Latin vacuus, empty; see vacuum.]

vac′u·o′lar (-ō′lər, -lär′) adj.
vac′u·o·la′tion n.
American Heritage® Dictionary of the English Language, Fifth Edition. Copyright © 2016 by Houghton Mifflin Harcourt Publishing Company. Published by Houghton Mifflin Harcourt Publishing Company. All rights reserved.


(ˌvæk yu əˈleɪ ʃən, -yəˈleɪ-)

1. the formation of vacuoles.
2. the state of being vacuolate.
3. a system of vacuoles.
Random House Kernerman Webster's College Dictionary, © 2010 K Dictionaries Ltd. Copyright 2005, 1997, 1991 by Random House, Inc. All rights reserved.
ThesaurusAntonymsRelated WordsSynonymsLegend:
Noun1.vacuolation - the state of having become filled with vacuolesvacuolation - the state of having become filled with vacuoles
condition, status - a state at a particular time; "a condition (or state) of disrepair"; "the current status of the arms negotiations"
Based on WordNet 3.0, Farlex clipart collection. © 2003-2012 Princeton University, Farlex Inc.
References in periodicals archive ?
(76,79) The histopathologic pattern is that of epidermolytic hyperkeratosis (EHK), in which the keratinocytes in the granular and spinous layers display cytoplasmic vacuolation, reticular degeneration, coarse keratohyalin granules, and perinuclear eosinophilic inclusions (Figure 8, B).
(11) Pulmonary lesions included edema, fibroplasia, infiltrations, hemorrhage, periarteritis, endothelial swelling and vacuolation, lymphoid hyperplasia, congestion, and thrombosis.
The classification of the severity of histopathological changes observed were: Stage I: cytoplasmic vacuolation, inflammatory infiltrate, infiltration of adipocytes; Stage II: congestion and steatosis; Stage III: granuloma.
In Case 2, H & E staining displayed vacuolation and fragmentation of muscle fibers, with orange-colored inclusion bodies in a significant amount of degenerated fibers, and immunohistochemistry staining revealed the absence of membrane protein of sarcoglycan.
There was an increase in interstitial fibrosis; many of the fibers appeared degenerative, some showed extensive vacuolation, and others were in the process of regenerating.
In study by Parihar et al.30 all the cases showed epidermal thinning and pigment incontinence, and 85% cases showed basal layer vacuolation.
According to the severity, sinusoidal dilatation, inflammatory cell infiltration, congestion, degeneration, and cytoplasmic vacuolation were scored as 0 (normal), 1 (mild), 2 (moderate), and 3 (severe).
(a) Shows Endometrial Glands in Secretory Phase, H and E 100x, (b) Shows Endometrial Gland in Secretory Phase Exhibiting Subnuclear Vacuolation and Stroma showing Decidual Changes, H and E, 400x, (c) Shows Endometrial Glands in Proliferative Phase, H and E, 100x, (d) Shows Endometrial Glands in Disordered Proliferative Phase, H and E, 100x
(2,3) The illness is hypothesized to arise from the production of misfolded prion proteins, ultimately leading to vacuolation, neuronal loss, and the spongiform appearance characteristic of CJD.
The examinations focused on renal tubules for the presence of dilatation, vacuolation, apoptosis, and necrosis.