(76,79) The histopathologic pattern is that of epidermolytic hyperkeratosis (EHK), in which the keratinocytes in the granular and spinous layers display cytoplasmic vacuolation
, reticular degeneration, coarse keratohyalin granules, and perinuclear eosinophilic inclusions (Figure 8, B).
(11) Pulmonary lesions included edema, fibroplasia, infiltrations, hemorrhage, periarteritis, endothelial swelling and vacuolation
, lymphoid hyperplasia, congestion, and thrombosis.
Heart section from BJME-treated rat showing distorted histological framework of the myocardium with evidence of vacuolation
(thick arrows) and necrosis (thin arrows); C.
The classification of the severity of histopathological changes observed were: Stage I: cytoplasmic vacuolation
, inflammatory infiltrate, infiltration of adipocytes; Stage II: congestion and steatosis; Stage III: granuloma.
in the white matter of the brain and the spinal cord as well as demyelination and axonal degeneration have been described.
In Case 2, H & E staining displayed vacuolation
and fragmentation of muscle fibers, with orange-colored inclusion bodies in a significant amount of degenerated fibers, and immunohistochemistry staining revealed the absence of membrane protein of sarcoglycan.
There was an increase in interstitial fibrosis; many of the fibers appeared degenerative, some showed extensive vacuolation
, and others were in the process of regenerating.
In study by Parihar et al.30 all the cases showed epidermal thinning and pigment incontinence, and 85% cases showed basal layer vacuolation
According to the severity, sinusoidal dilatation, inflammatory cell infiltration, congestion, degeneration, and cytoplasmic vacuolation
were scored as 0 (normal), 1 (mild), 2 (moderate), and 3 (severe).
(a) Shows Endometrial Glands in Secretory Phase, H and E 100x, (b) Shows Endometrial Gland in Secretory Phase Exhibiting Subnuclear Vacuolation
and Stroma showing Decidual Changes, H and E, 400x, (c) Shows Endometrial Glands in Proliferative Phase, H and E, 100x, (d) Shows Endometrial Glands in Disordered Proliferative Phase, H and E, 100x
(2,3) The illness is hypothesized to arise from the production of misfolded prion proteins, ultimately leading to vacuolation
, neuronal loss, and the spongiform appearance characteristic of CJD.
The examinations focused on renal tubules for the presence of dilatation, vacuolation
, apoptosis, and necrosis.