In another study,6 dexamethasone-induced spermatogenesis defects including epithelial vacuolisation
, sloughing of germ cells, reduction of seminiferous tubule diameter, reduction in the number of sperm heads and significant maturation arrest were in agreement with the present study.
In addition, exocytosis of lymphocytes and vacuolisation
of stratum malpighii was seen in one case respectively, whereas focal spongiosis was present in 2 biopsies.
There are several pathogenicity factors that influence gastric mucosa damage such as vacuolating cytotoxin A (VacA), that causes vacuolisation
in epithelial cells, cell death and epithelial integrity destruction; on the other hand, cytotoxin associated to A gene (CagA), coded in a pathogenicity island is associated with severe gastritis, nasal mucosa atrophy, high risk of ulcer and gastric cancer .
After proper tissue fixation, processing and haematoxylin and eosin staining, the section revealed cystic lining with changes like basal cell nuclei palisading with reverse polarity and sub nuclear vacuolisation
Deformation at nucleus structure of cortical alveoli vacuolisation
inner part of oocyte expansion between vitelline membrane and zona radiata and atretic follicule were seen (Fig.
A caudal cell mass composed of pluripotent cells ascends from the tail bud of the embryo and, through a process of vacuolisation
, forms a central canal that connects to the rostral cord formed during primary neurulation.
The cytotoxicity reactivity were graded based on the zone of lysis, vacuolisation
, detachment and membrane as given in Table 1.
12 Concentration Treatment Disorders of Extended Chromosome [micro]g/ml Duration Chromosome prophase vacuolisation
(hour) spiralisation No.
We also observed a cytoplasmic vacuolisation
in hepatocytes from the treated animals (Figure 1).
Lesions thought to be due to myelin vacuolisation
either remain static or decrease with time and are not clinically associated with disease severity.
1,2,3) Tubular adenomas are characterised by uniform closely approximated tubular structures lined by epithelial and myoepithelial cells with little or no cytoplasmic vacuolisation
Myocardial biopsy studies of patients exposed to anthracyclines show ultrastructural changes in cardiac muscle with vacuolisation
and myocyte dropout.