valdecoxib


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Related to valdecoxib: rofecoxib, Parecoxib
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Noun1.valdecoxib - a Cox-2 inhibitor (trade name Bextra) that relieves pain and inflammation without harming the digestive tractvaldecoxib - a Cox-2 inhibitor (trade name Bextra) that relieves pain and inflammation without harming the digestive tract
Cox-2 inhibitor - an anti-inflammatory drug that fights pain and blocks Cox-2 activity without impeding the activity of Cox-1; increases the risk of heart attacks; "Cox-2 inhibitors reduce the symptoms of arthritis without endangering the stomach and kidneys"
Translations

valdecoxib

n valdecoxib m
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References in periodicals archive ?
Celecoxib, roficoxib, parecoxib, and valdecoxib are among the members of this class.
Its role in the production of inflammatory [PGE.sub.2] and probably prostacyclin ([PGI.sub.2]) provided the rationale for the development of COX-2 selective NSAIDs, such as celecoxib, rofecoxib, and valdecoxib, for the management of pyrexia, relief of pain, and alleviation of inflammation with less gastrointestinal side effects [2].
[3] have reported that the blocking of cox-2 activity in cAD rats by valdecoxib (specific cox-2 inhibitor) resulted in better recovery of memory impairment, oxidative stress, and acetylcholine esterase activity compared to that of nonspecific cox blocker, naproxen, in a 25-day study indicating an important role of cox-2 on the colchicine induced memory impairments and stress parameters.
Similar data were reported in another study whose patients were given valdecoxib [9].
Analgesics like rofecoxib and valdecoxib, the COX-2 inhibitors can cause thrombi formation which increases the risk of cardiovascular events Hepatic [17,20] Hepatotoxicity occurs after the patient ingests 150 to 250 mg/kg of paracetamol as a single dose.
Posteriormente otros representantes de esta misma familia quimica fueron retirados del mercado farmaceutico por sus efectos colaterales, entre los cuales se encuentran el parecoxib, valdecoxib y lumiracoxib.
The study suggested an increased risk of stroke with rofecoxib (Vioxx) and valdecoxib (Bextra), compared with the effects of nonselective agents (Stroke 2008;39:2037-45).
Celecoxib, valdecoxib ve non selektif NSAII icin kardiyovaskuler toksisite konusunda ise kesin kanit yoktur (11,12).
Analgesic NNT Etoricoxib 180/240 1.5 Valdecoxib 20mg 1.7 Ketorolac 20mg 1.8 Diclofenac 100mg 1.9 Piroxicam 40mg 1.9 Naproxen 440mg 2.0 Parecoxib i.v 40mg 2.2 Paracetamol 1000mg + codeine 60mg 2.2 Diclofenac 50mg 2.3 Ibuprofen 400mg 2.4 Ibuprofen 200mg 2.7 Parecoxib 20mg 3.0 Paracetamol 500mg 3.5 Paracetamol 1000mg 3.8 Celecoxib 200mg 4.5 Figure 2: Synthesis, function and inhibition of COX-1 and COX-2 isoenzymes Enzyme COX-1 COX-2 Synthesis Constitutive Inducible Functions Gastric protection Pro-inflammatory Platelet aggregation prostaglandins Vascular tone Renal blood flow Sodium excretion COX-1 COX-2 Inhibition by NSAIDs Indomethacin Aspirin Pirioixcam Ibuprofen Diclofenac Celecoxib Lumiracoxib Etoricoxib
Oral valdecoxib and injected parecoxib for acute postoperative pain: a quantitative systematic review.
Levy received support through an independent research grant from Pfizer, manufacturer of valdecoxib. Dr.
Understandably, this discovery precipitated a careful review of all NSAIDs, whether COX-1 inhibitors (including ibuprofen) or COX-2 inhibitors (celecoxib, valdecoxib, etoricoxib)--but it did not lead to greater scrutiny of acetaminophen.