Celecoxib, roficoxib, parecoxib, and valdecoxib
are among the members of this class.
Its role in the production of inflammatory [PGE.sub.2] and probably prostacyclin ([PGI.sub.2]) provided the rationale for the development of COX-2 selective NSAIDs, such as celecoxib, rofecoxib, and valdecoxib
, for the management of pyrexia, relief of pain, and alleviation of inflammation with less gastrointestinal side effects .
 have reported that the blocking of cox-2 activity in cAD rats by valdecoxib
(specific cox-2 inhibitor) resulted in better recovery of memory impairment, oxidative stress, and acetylcholine esterase activity compared to that of nonspecific cox blocker, naproxen, in a 25-day study indicating an important role of cox-2 on the colchicine induced memory impairments and stress parameters.
Similar data were reported in another study whose patients were given valdecoxib
Analgesics like rofecoxib and valdecoxib
, the COX-2 inhibitors can cause thrombi formation which increases the risk of cardiovascular events Hepatic [17,20] Hepatotoxicity occurs after the patient ingests 150 to 250 mg/kg of paracetamol as a single dose.
Posteriormente otros representantes de esta misma familia quimica fueron retirados del mercado farmaceutico por sus efectos colaterales, entre los cuales se encuentran el parecoxib, valdecoxib
The study suggested an increased risk of stroke with rofecoxib (Vioxx) and valdecoxib
(Bextra), compared with the effects of nonselective agents (Stroke 2008;39:2037-45).
ve non selektif NSAII icin kardiyovaskuler toksisite konusunda ise kesin kanit yoktur (11,12).
Analgesic NNT Etoricoxib 180/240 1.5 Valdecoxib
20mg 1.7 Ketorolac 20mg 1.8 Diclofenac 100mg 1.9 Piroxicam 40mg 1.9 Naproxen 440mg 2.0 Parecoxib i.v 40mg 2.2 Paracetamol 1000mg + codeine 60mg 2.2 Diclofenac 50mg 2.3 Ibuprofen 400mg 2.4 Ibuprofen 200mg 2.7 Parecoxib 20mg 3.0 Paracetamol 500mg 3.5 Paracetamol 1000mg 3.8 Celecoxib 200mg 4.5 Figure 2: Synthesis, function and inhibition of COX-1 and COX-2 isoenzymes Enzyme COX-1 COX-2 Synthesis Constitutive Inducible Functions Gastric protection Pro-inflammatory Platelet aggregation prostaglandins Vascular tone Renal blood flow Sodium excretion COX-1 COX-2 Inhibition by NSAIDs Indomethacin Aspirin Pirioixcam Ibuprofen Diclofenac Celecoxib Lumiracoxib Etoricoxib
and injected parecoxib for acute postoperative pain: a quantitative systematic review.
Levy received support through an independent research grant from Pfizer, manufacturer of valdecoxib
Understandably, this discovery precipitated a careful review of all NSAIDs, whether COX-1 inhibitors (including ibuprofen) or COX-2 inhibitors (celecoxib, valdecoxib
, etoricoxib)--but it did not lead to greater scrutiny of acetaminophen.