variable region


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variable region

n.
The portion of an immunoglobulin molecule's heavy and light chains that has a variable amino acid sequence and determines the molecule's antigenic specificity.
References in periodicals archive ?
Ibrutinib-rituximab resulted in better progression-free survival than chemoimmunotherapy in patients without immunoglobulin heavy-chain variable region (IGHV) mutation (90.7 versus 62.5 percent at three years; hazard ratio for progression or death, 0.26; 95 percent CI, 0.14 to 0.50).
With its variable region, it specifically binds antigens, which also include pathogens.
Table-2: Annealing positions of reverse primer VDLDr-R on reference DNA sequences of hyper variable region 18-S rRNA gene of Microsporum and Trichophyton
However, plasmid pPV989-94 contained a variable region that was a mobile genetic element mediated by the phage integrase and site-specific recombinase, and the region carried genes related to glycometabolism, resistance, and DNA repair.
Epitope Mapping of Antibodies Directed Against Hyper Variable Region 1 in Acute Selflimiting and Chronic Infection due to Hepatitis C Virus.
The gene present at pilE locus has both conserved and variable regions while that present at pilS locus mainly contains variable region.
Methods: Taking advantage of a population of 406 untreated Chinese patients with CLL at early and advanced stage of disease, we identified the strongest prognostic markers of TTFT and, subsequently, in a cohort of 173 patients who had complete data for all 3 variables, we integrated the data of traditional staging system, cytogenetic aberrations, and mutational status of immunoglobulin heavy chain variable region (IGHV) in CLL-PI.
It was also reported that the variable region of P3 is shared by the antibody A4ac, isolated from a mouse with experimental allergic encephalomyelitis, which recognizes myelin oligodendrocytes [2].
It should be noted that though in theory the identification of common sequence(s) in two independent selections with an [N.sub.40] (variable region of the Library) is very low, we reason that when the starting DNA template is transcribed, specific sequences may be represented multiple times in the starting RNA library, which is then used for separate selections.
In terms of determining impact what would be more insightful would be to add STRIVE Components (as a controlling variable) to the existing variable Region and see how this addition makes an impact on the NAT scores.
The sequence of cagA 3' variable region in 164 strains were obtained including East Asian-type (122 74.39%) and Western-type (42 25.61%).

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