variable region


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variable region

n.
The portion of an immunoglobulin molecule's heavy and light chains that has a variable amino acid sequence and determines the molecule's antigenic specificity.
References in periodicals archive ?
The gene present at pilE locus has both conserved and variable regions while that present at pilS locus mainly contains variable region.
Methods: Taking advantage of a population of 406 untreated Chinese patients with CLL at early and advanced stage of disease, we identified the strongest prognostic markers of TTFT and, subsequently, in a cohort of 173 patients who had complete data for all 3 variables, we integrated the data of traditional staging system, cytogenetic aberrations, and mutational status of immunoglobulin heavy chain variable region (IGHV) in CLL-PI.
In terms of determining impact what would be more insightful would be to add STRIVE Components (as a controlling variable) to the existing variable Region and see how this addition makes an impact on the NAT scores.
The sequence of cagA 3' variable region in 164 strains were obtained including East Asian-type (122 74.
Although all of the methods described above have been analogous to current clinical assays, both groups have also worked in parallel on disease-specific immunoglobulin quantification using peptides from the variable region of the monoclonal immunoglobulin secreted by MM tumor cells (6, 9).
and colleagues analyzed DNA in a highly variable region of the lichen's fungal component.
VEB-1a] gene and in the class 1 integron variable region (5'CS-3'CS) (Eurogentec, Belgium) as described previously.
DARPins are nonantibody-based small proteins where a variable region has been engineered for target binding.
Forward primer S-D-Bact-339-a-S-20 (5' CTC CTA CGG GAGGCAGCAGT 3') and reverse primer S-D-Bact-788-a-A-19 (5' GGA CTA CCA GGG TAT CTA A 3') were used for amplifying the variable region 3 and 4 of the bacterial 16S rRNA genes in PCR (10).
CLL samples were classified into immunoglobulin heavy chain variable region (IGHV) gene mutated (n=55) and unmutated (n=29) and also indolent (n=42) and progressive (n=39) subtypes.

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