vascular endothelial growth factor


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Related to vascular endothelial growth factor: Platelet derived growth factor

vascular endothelial growth factor

n. Abbr. VEGF
Any of a family of signaling proteins that cause the proliferation of endothelial cells and the development of blood vessels. They are active during normal processes such as embryogenesis and also during certain pathological processes, such as the growth of malignant tumors. Several cancer drugs have been developed that inhibit the activity of these proteins or their cell receptors.
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References in periodicals archive ?
Tivozanib is an oral, once-daily, potent and highly-selective vascular endothelial growth factor receptor tyrosine kinase inhibitor.
TGFB1 induces the vascular endothelial growth factor expression (34, 43).
Key Words: Moderate exercise, Vascular endothelial growth factor, Wound healing, Wistar rats
* Replenishing four growth factors--epidermal growth factor (EGF), insulin-like growth factor-1 (IGF-1), vascular endothelial growth factor (VEGF), fibroblast growth factor (FGF)--through topical application has been shown to diminish wrinkles, improve elasticity, and restore moisture to rejuvenate aging skin.
Chang et al., "Vascular dysfunction induced by elevated glucose levels in rats is mediated by vascular endothelial growth factor," Journal of Clinical Investigation, vol.
Giacomelli, "Angiogenic and angiostatic factors in systemic sclerosis: increased levels of vascular endothelial growth factor are a feature of the earliest disease stages and are associated with the absence of fingertip ulcers," Arthritis Research, vol.
IL-1 gene expression, chemokines, adhesion molecules, transforming growth factor-[beta]1, and vascular endothelial growth factor also significantly increased compared with IL-6-deficient BALB/c mice [14].
Jabbour, "Expression and regulation of the prokineticins (endocrine gland-derived vascular endothelial growth factor and Bv8) and their receptors in the human endometrium across the menstrual cycle," The Journal of Clinical Endocrinology and Metabolism, vol.
Sage, "Regulation of retinal capillary cells by basic fibroblast growth factor, vascular endothelial growth factor, and hypoxia," In Vitro Cellular & Developmental Biology.
To promote proliferation of malignant tumors, factors related to angiogenesis such as vascular endothelial growth factor (VEGF) and cluster of differentiation 34 (CD34) are always overexpressed.
In angiogenesis, several cytokines play important roles, but the vascular endothelial growth factor (VEGF) is considered to be vital (Arras et al., 1998).

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