PhaseBio's second product candidate PB1046, which is based on ELP, is a once-weekly vasoactive
intestinal peptide receptor agonist for the treatment of pulmonary arterial hypertension.
For patients with sudden sensorineural hearing loss, clinicians should not order routine computed tomography of the head in the initial evaluation, should not obtain routine laboratory tests, and should not routinely prescribe antivirals, thrombolytics, vasodilators, or vasoactive
Lastly ocreotide suppresses the secretion of vasoactive
intestinal peptide (VIP) that can increase the heart rate.
There were no difference of the duration of surgery, the requirement of vasoactive
agents and the bleeding volume between two groups (P>0.05).
PB1046 is a sustained-release analogue of human vasoactive
intestinal peptide, or VIP, fused to PhaseBio's proprietary ELP half-life extension technology.
However, varicella-zoster viruses destroy nerve cells and lead to the production of endogenous neuropeptides, such as substance P and vasoactive
intestinal peptide, which play important roles in angiogenesis and promote the proliferation of vascular cell as well as endothelial growth factor expression.
In this group, 6 children required 1 vasoactive
agent, 3 children required 2 vasoactive
agents, and 2 children required 3 vasoactive
Mast cells are located close proximity to blood vessels and nerves in the dura mater and contain a wide variety of neuroactive and vasoactive
mediators such as adenosine triphosphate (ATP), adenosine, substance-P (SP), calcitonin gene related peptide (CGRP), vasoactive
intestinal peptide (VIP), histamine, serotonin (5-HT), nitric oxide (NO) and even proinflammatory cytokines such as tumor necrosis factor alpha (TNF-a) in their granules (7).
The following data were collected: age, gender, date of hospitalization, medical ward, underlying medical condition, co-morbidities (liver, lung, cardiac, neurologic or renal disease), receipt of transplant, hemodialysis, parenteral nutrition, mechanical ventilation, surgery (of any type requiring any anesthesia other than local anesthesia within the 3 months prior to the incident candidemia), neutropenia (<500 neutrophils/[mm.sup.3]), central venous catheter (CVC), receipt of corticosteroids, H2 blockers, antibiotics or antifungal agents (in the previous 2 weeks), APACHE II score on the day of the incident candidemia, hypotension or receipt of vasoactive
drugs in the previous 2 days, fever, antifungal treatment, and the outcome (alive or dead 30 days after the incident candidemia).
drugs currently used in the management of acute variceal bleeding are terlipressin, somatostatin and octreotide.