verapamil


Also found in: Thesaurus, Medical, Encyclopedia, Wikipedia.

ve·rap·a·mil

 (və-răp′ə-mĭl′)
n.
A calcium channel blocker drug, C27H38N2O4, that acts as a coronary vasodilator and is used in its hydrochloride form to treat hypertension and certain cardiac arrhythmias.

[vera(tryl), one of its constituents (from New Latin Vērātrum, hellebore genus; see veratrine) + -pamil, vasodilating drug suffix (perhaps p(ropyl) + am(ino) + (nitr)il(e)).]

verapamil

(vɪˈræpəˌmɪl)
n
(Pharmacology) med a calcium-channel blocker used in the treatment of angina pectoris, hypertension, and some types of irregular heart rhythm

ve•ra•pam•il

(ˌvɪər əˈpæm əl, ˌvɛr-)

n.
a white, crystalline powder, C27H38N2O4, used as a calcium blocker in the treatment of angina and certain arrhythmias.
[1965–70]
ThesaurusAntonymsRelated WordsSynonymsLegend:
Noun1.verapamil - a drug (trade names Calan and Isoptin) used as an oral or parenteral calcium blocker in cases of hypertension or congestive heart failure or angina or migraine
calcium blocker, calcium-channel blocker - any of a class of drugs that block the flow of the electrolyte calcium (either in nerve cell conduction or smooth muscle contraction of the heart); has been used in the treatment of angina or arrhythmia or hypertension or migraine
Translations

verapamil

n verapamilo, verapamil m
References in periodicals archive ?
Importantly, the pattern of CPF recovery in hearts perfused with high dose of TGS (25 and 50 mg/ml) is different from that of non-treated control hearts or verapamil treated hearts.
Other medications that are metabolized by this isoenzyme include haloperidol, olanzapine, thioridazine, tacrine, amitriptyline, imipramine, clomipramine, warfarin, propranolol, methadone, verapamil, and theophylline, Dr.
In similar tests, the same cell lines became five to 10 times more sensitive to adriamycin when exposed to verapamil, a compound that binds to and closes off the protein pump.
in connection with a dispute involving Verapamil ER.
Verapamil (Calan, Isoptin) and selective serotonin-reuptake inhibitors (SSRIs) also were widely used, but the reviewers concluded that there was poor evidence of benefit.
Trandolapril is also marketed by Abbott as a fixed-combination product with verapamil, a calcium channel blocker, under the trademark of Tarka(R), and by Aventis under the trademark Ocadrik(R).
Scientists have looked at the well-known pump-blocking drug verapamil as a way to reverse drug resistance (SN:4/13/85, p.
This extended-release, controlled-onset drug delivery system results in a maximum plasma concentration of verapamil during these early-morning hours when prescribed as a once daily bedtime dosage.
Thus, our present study was to investigate the intestinal absorptive behavior of cryptotanshinone using the in vitro everted rat gut sac model in the absence and the presence of coexisting diterpenoid tanshinones, danxingfang and the P-gp inhibitor verapamil, in order to reveal the possible mechanisms of improving the bioavailability of cryptotanshinone in vivo.
Remuzzi and his associates conducted a multicenter, double-blind, placebo-controlled, randomized trial, comparing monotherapy with verapamil with combination treatments for patients with type 2 diabetes and normal renal function.