Pathological Observations: Compared with the blank group, the results indicated that in the positive drug group, the small intestinal villi
were sloughed, and some of which even disaggregated.
Distal villous hypoplasia and increased syncytial knots (aggregation of syncytiotrophoblastic nuclei on the periphery of tertiary placental villi
, forming a huge multinucleated protrusion from the villous surface) can also be visualized8.
were counted from nine different sections in each segment (duodenum, jejunum, and ileum) per bird, and their average was expressed as the mean villus height and villus width for each bird.
(13-15) Examination of villi
may reveal the characteristic cytomegaly with intranuclear and intracytoplasmic inclusions (Figure 1, A and B).
Instead, the remains of villi
appear to constitute a various structures (convolutions and mosaic plateau) down the line, with the surface epithelia lying well above the openings of individual crypt tubes (Figure 1).
This results supported by Bartell and Batal  and Soltan , who observed that consumption of 1.0% Gln in broilers, resulted in longer villi
height and higher relative weights of duodenum and jejunum, and consequently higher BWG.
layer of hairlike protrusions called villi
. Microvilli are similar and
Morphological Features of the Human Placenta and its Free Chorionic Villi
in Normal Pregnancies and those with Diabetes and High Blood Pressure.
One of the histo-morphologic features to be evaluated is the vascularity of chorionic villi
. The number of vascular channels present in terminal villi
ranges from 2 to 6 and if the number increases beyond this then it is termed as 'villous hypervascularity (1).' The term 'chorangiosis' was introduced by Altshuler in 1984 and is defined as the presence of [greater than or equal to]10 terminal villi
, each containing [greater than or equal to]10 capillaries per terminal villus in [greater than or equal to]10 low power (10x) fields in at least 3 or more random, non-infarcted cotyledons of the placenta (2).
The Cambridge team grew the organ models using cells from villi
, tiny frond-like structures, taken from placental tissue.
The method, which we call CypCel is based on a drug biomarker simvastatin, a cholesterol reducing medication, that has the unusual property of being highly metabolised in the small intestine by the enzyme CYP3A4, which is expressed on the villi
appear in the duodenum and proximal jejunum by 7 weeks.