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Related to vincristine: cyclophosphamide, methotrexate, prednisone


An alkaloid, C46H56N4O10, originally obtained from the Madagascar periwinkle and used in its sulfate form to treat acute leukemia and a variety of other neoplasms.

[New Latin Vinca, periwinkle genus; see vinca + Latin crista, crest; see crest + -ine.]
American Heritage® Dictionary of the English Language, Fifth Edition. Copyright © 2016 by Houghton Mifflin Harcourt Publishing Company. Published by Houghton Mifflin Harcourt Publishing Company. All rights reserved.


(Pharmacology) a cytotoxic drug used in the treatment of leukaemia, derived as an alkaloid from the tropical shrub Madagascar periwinkle (Vinca rosea)
[C20: from New Latin vinca + Latin crista crest + -ine2]
Collins English Dictionary – Complete and Unabridged, 12th Edition 2014 © HarperCollins Publishers 1991, 1994, 1998, 2000, 2003, 2006, 2007, 2009, 2011, 2014


(vɪnˈkrɪs tin)

an alkaloid, C46H56N4O10, derived from the periwinkle, Vinca rosea, used in treating certain cancers.
[1960–65; < New Latin Vin(ca) a periwinkle genus + Latin crist(a) crest + -ine2]
Random House Kernerman Webster's College Dictionary, © 2010 K Dictionaries Ltd. Copyright 2005, 1997, 1991 by Random House, Inc. All rights reserved.
ThesaurusAntonymsRelated WordsSynonymsLegend:
Noun1.vincristine - periwinkle plant derivative used as an antineoplastic drug (trade name Oncovin); used to treat cancer of the lymphatic system
periwinkle plant derivative - an antineoplastic drug used to treat some forms of cancer
Based on WordNet 3.0, Farlex clipart collection. © 2003-2012 Princeton University, Farlex Inc.


n vincristina
English-Spanish/Spanish-English Medical Dictionary Copyright © 2006 by The McGraw-Hill Companies, Inc. All rights reserved.
References in periodicals archive ?
Regimen-A included three drugs (dexamethasone, vincristine and asparaginase) and Regimen-B included four drugs (dexa-methasone, vincristine, asparaginase and daunorubicin) Remission status was assessed after 1 month of induction chemotherapy by blood complete counts and bone marrow examination.
In 2016, Hataet al.,retrospectively analyzed the long-term outcome of a case series (36 patients) with OD treated with RTand procarbazine, nimustine, vincristine (PAV) therapy.3 Their results showed that IDH mutation and 1p/19q loss were the prognostic factors to consider for OD, not WHO grade, furthermore there was a significantly better prognosis for patients with 1p/19q co-deletion.
In our centre, adolescent and adult ES patients (age > 16 years) with localized and metastatic disease have been treated between 1990 and 2014 with two alternating chemotherapy regimens: VIA (vincristine, ifosfamide, and doxorubicin) and VIP (etoposide, ifosfamide, and cisplatin).
The risk of paralytic ileus after treatment with vincristine must be borne in mind when treating gastrointestinal lymphomas [15, 16].
Vincristine is a frequently used chemotherapeutic agent in childhood malignancies.
[11] Published treatment guidelines for the management of KS in resource-limited settings include chemotherapy with the single drugs etoposide, thalidomide and vincristine, with two drugs, namely vincristine and bleomycin, and with three drugs, namely doxorubicin (Adriamycin), bleomycin and vinblastine sulphate.
This patient was treated with vincristine, actinomycin, and cyclophosphamide with recurrence of SLCT 7 years later [21].
Induction of Neuropathic Pain with Vincristine. To induced neuropathy in Sprague-Dawley rats, vincristine sulphate (100 [micro]g/kg) was administrated (i.p.) into the hindpaw in two series of 5 successive working days (1, 2, 3, 4, and 5 days and then 8, 9, 10, 11, and 12 days) [32].
In this study we assess the efficacy of vincristine sulphate, a vinca alkaloid used in cancer therapy, in inducing and sustaining remission in SRNS.
The drugs include procarbazine, lumostine, and vincristine. The combination group also had better disease-free survival of 10.4 years vs.