Results from the pivotal Phase 3 EMERALD study showed that a once-daily STR containing darunavir 800 mg, cobicistat 150 mg, emtricitabine 200 mg and tenofovir alafenamide 10 mg [D/C/F/TAF] had a low cumulative virologic
rebound rate and a high virologic
suppression rate at 24 weeks in human immunodeficiency virus type 1 (HIV-1) positive, virologically suppressed adults who switched from a standard boosted protease inhibitor regimen.
SAN FRANCISCO -- Once-daily treatment with fixed-dose combination sofosbuvir/velpatasvir for 12 weeks was well tolerated and resulted in high sustained virologic
response rates in hepatitis C-infected patients in the phase III ASTRAL-1 study.
Rates of virologic
failure (a detectable viral load * during antiretroviral therapy) fell from over 60% in 1997-1998 to under 10% in 2009-2011 in France.
In addition, the combination of three different mechanisms of action interrupts the hepatitis C virus replication process with the goal of optimizing sustained virologic
response rates across different patient populations.
A combined regimen of daclatasvir and sofosbuvir achieved sustained virologic
response rates greater than 90% in an industry-sponsored trial involving patients with chronic HCV, according to study published online Jan.
The improved potency and tolerability of antiretroviral (ARV) drugs and the accumulated knowledge about their ideal combination enabled a higher proportion of long-term virologic
suppression in randomized clinical trials of initial ARV therapy (ART) in HIV-1-infected patients.
Although we observed an independent association between coffee intake and virologic
response to treatment, this association needs replication in other studies," he said.
1) In women with hepatitis C virus genotype 1 infection who were found to exhibit insulin resistance, taking metformin in addition to standard hepatitis C therapy resulted in a doubled sustained virologic
response and greater decrease in viral load compared to placebo in the first 12 weeks of treatment.
After the 48-week trial concluded, 75% of those in the boceprevir group had a sustained virologic
response (SVR)--meaning undetectable levels of virus.
surveillance began in Lao PDR in July 2005.
Measuring the actual effect of adherence on virologic
and resistance outcomes in HIV-infected injection drug users (IDUs): A longitudinal study.
The randomized study of 218 women and 30 infants in Botswana found that, for the cohorts as a whole, the peripartum nevirapine dose led to higher rates of virologic
failure in women and their infants, compared with women who received a peripartum dose of placebo and their infants, she said at the annual meeting of the Infectious Diseases Society of America.