* Oncolytic virotherapy
is an emerging therapeutic option for cancer treatment.
In addition to his role as center director and professor of the Biodesign Center for Immunotherapy, Vaccines and Virotherapy
at ASU, Dr.
as an immunotherapeutic strategy for multiple myeloma.
The first genetically unmodified oncolytic virotherapy
"This study has clearly confirmed that oncolytic virotherapy
is able to create an inflamed phenotype and sensitize the tumor to immune checkpoint blockade," said Dr.
It's very significant because it shows, contrary to recent scientific claims, that virotherapy
can be combined with cell therapy for a positive effect," said the study's corresponding author Balveen Kaur, Ph.D., professor and vice chair of research in the Vivian L.
Previous scientific wisdom discredited combining virotherapy
and externally added NK cell therapy to the body's natural killer (NK) cells, but there could be clear cancer-fighting benefits - providing enough external NK cells are deployed to destroy the tumor and stop its spread, as revealed in this paper.
In the present paper, we report about our experience gained with PIPAC since July 2016 at a tertiary cancer center offering all other therapeutic options for peritoneal metastasis, including in particular palliative systemic chemotherapy, intraperitoneal chemotherapy, intraperitoneal virotherapy
, cytoreductive surgery, and hyperthermic intraperitoneal chemotherapy (HIPEC).
Neutralizing antibodies are highly prevalent and can reduce the efficacy of repeat injections although how antivector immunity influences the clinical or biologic response of intratumoral virotherapy
is not known.
One emerging treatment modality is oncolytic virotherapy
. This technique involves targeting cancer cells using oncolytic viruses (OVs), standard viruses genetically engineered to replicate selectively in cancer cells.