ACV, acellular vaccine; Prn, pertactin; WCV, whole-cell vaccine
No substantive changes have been made to ACIP typhoid vaccine recommendations apart from removing the discontinued parenteral whole-cell vaccine
from the list of available typhoid vaccines.
"The use of the whole-cell vaccine
after the initial vaccination in the first year of life might be a good idea, but we don't know yet if that would correct the immunological defects of the acellular vaccine.
A controlled trial of two acellular vaccines and one whole-cell vaccine
That inactivated, whole-cell vaccine
offers up the full pertussis bacterium, bristling with scores of proteins that our bodies recognize as foreign and build an immune response against.
In another Kaiser Permanente study that zeroed in on the transition period between the use of whole-cell pertussis vaccine and DTaP, patients who contracted PCR-confirmed pertussis did so an average of 14.7 years after receiving the last dose in the series if they received one or more doses of whole-cell vaccine
compared with 5.6 years after the last dose if they got the all-DTaP series.
The study found teens who were vaccinated with four doses of acellular vaccine were at almost six times higher risk of pertussis than those who had received four doses of whole-cell vaccine
. Health officials have switched to the acellular vaccine in recent years because of risks related to the whole-cell formulation.
Polymorphism of Bordetella pertussis isolates circulating the last ten years in France, where a single effective whole-cell vaccine
has been used for more than thirty years.
"The durability of protection with the acellular vaccine is not as good as with the whole-cell vaccine
, but the problem with the whole-cell vaccine
was that it was quite reactive," causing local reactions and fevers, she said in an interview.
Evidence of Bordetella pertussis infection in adults presenting with persistent cough in a French area with very high whole-cell vaccine
8, 1996 New England Journal of Medicine demonstrated that the acellular pertussis vaccines provide disease protection and provoke fewer reactions than the whole-cell vaccine
Whole-cell pertussis vaccines were more immunogenic, so immunity lasted longer, but the reason for that was the contamination of the whole-cell vaccine