These features should prompt a closer inspection for xanthomatous
(foam) cells, which are confined to the dermal papillae (Figure 9, C).
(9,10) In a great white pelican (Pelecanus onocrotalus) with subcutaneous xanthomatosis (11) and a goose (Anser anser) with atypical multiple, xanthomatous
, cutaneous neoplasia, (12) hyperlipidemia was thought to be a potential cause.
Based on histopathologic examination, which is needed to confirm the diagnosis, primary hypophysitis can be categorized into five groups: lymphocytic, granulomatous, xanthomatous
, IgG4 plasmacytic, and necrotizing hypophysitis (NH) (2).
Examination revealed xanthomatous
infiltration of cornea and oral mucosa.
Among the connective tissue tumours, angioma is very common and nerve sheath tumours are seen less frequent, while others like Lipoma, Xanthomatous
tumours and Histiocytic tumours are still rare.
(7) Morphologically, foamy gland HG PIN is characterized by bland nuclei and abundant xanthomatous
cytoplasm with a distinct foamy appearance.
Histologically, PXA is characterized by spindle cells, multinucleated giant cells and foamy lipid-laden xanthomatous
The biopsy reported a carcinoma with cribriform xanthomatous
phenotype (Figure 4).
It can be associated with a moderate chronic foreign body inflammatory process type and rare xanthomatous
Microscopically, the hallmark of VX is the presence of foamy (xanthomatous
) cells in the connective tissue papillae [1-5].
Most notable findings on histological examination of APXA are pleomorphic, xanthomatous
tumour cells with intracytoplasmic lipid vacuoles.
The distinctive feature of xanthogranulomatous prostatitis is the presence of large number of foamy histiocytes (lipid-laden macrophages) also known as xanthomatous
cells admixed with other inflammatory cells.