The study 'KLF-1 orchestrates a xenobiotic
detoxification program essential for longevity of mitochondrial mutants' was now published in the journal 'Nature Communications'.
We deem that this topic appears extremely interesting, but at the same time controversial: it is known that NAT2 enzyme has a critical role in the initial biotransformation of multiple xenobiotic
substances (among all aromatic amines and hydrazines) and that several polymorphisms and alleles of its gene characterize the genome of general population (with different distribution in the world) (2).
These wastewaters contained organic micropollutants that affected signaling pathways, consistent with xenobiotic
metabolism; in addition, they caused toxicity to aquatic organisms such as Daphnia magna.
Objective: Biotransformation of xenobiotics
is critical for their metabolism and removal from the body which is carried out by xenobiotic
metabolism studies in rats, farm animals and plants identify and quantify the active ingredient and its related degradation products, i.e.
2006) modulate the expression of genes involved in xenobiotic
and energy homeostasis (Evans and Mangelsdorf 2014).
By doing so, I will also skip the important contribution of xenobiotic
oxidation on infertility for both sexes.
Nociceptive elements are grouped under the voice of xenobiotic
metabolism study is fundamental to a rational understanding of the pharmacology, toxicology research on cancer and addiction.
Genetical predisposition to resist xenobiotic
stress could, in principle, be explained in terms of single nucleotide polymorphisms (SNPs) of complex MDR system components, starting from drug transporters, censoring receptors, and xenobiotic/drug metabolising enzymes (see several examples below).
compounds are classified as any foreign chemical substance inside the biological system.
The constitutive levels of expression of xenobiotic-metabolizing enzyme in a tissue determine its ability to detoxify xenobiotic
compounds and endogenous metabolic stress.