In preclinical studies, ZW49 demonstrated complete tumor regressions in a panel of high and low HER2-expressing patient derived xenografts
and promising efficacy in a model of breast cancer brain metastases.
The use of various graft materials has been proposed over the years, such as autogenous bone grafts (Pelegrine et al., 2010), allografts (Wood & Mealey, 2012), xenografts
(Calasans-Maia et al., 2014), and alloplasts (Brkovic et al., 2012) to maintain the dimensions of the alveolar ridge after extraction.
The collection includes tumor models from a wide range of tumor subtypes for both in vivo and in vitro oncology research, including patient-derived xenografts
, cell line-derived xenografts
, and syngeneic models.
After the mice were sacrificed, the tumor xenografts
were excised, fixed in 10% buffered formalin, and embedded in paraffin for preparation of tissue sections (4 pm).
First preclinical PET imaging using CHO-K1-h[A.sub.3]AR xenografts
has shown promising results leading to further evaluation of this PET-tracer in oncology .
Recently, tumor tissues from surgical ablation have been increasingly used to reconstruct the patient-derived tumor xenografts
(PDTX) model by transplantation into immune-deficient mice.
Methods: We subcutaneously injected surgically resected CRC tissues from a patient into BALB/c-nu mice to build patient-derived xenografts
Since they can preserve cell-autonomous heterogeneity, human tumor xenografts
in immunodeficient mice have also led to valuable insights into the biology of human cancers.
In conjunction, Oncotest GmbH's integration with Charles River's broader portfolio of human xenografts
, syngeneic, and humanized immunotherapy research models, flow cytometry and IVIS imaging services as well as creates a premier oncology portfolio for the validation of novel cancer therapies.
Integrated with Charles River's broader portfolio of human xenografts
, syngeneic, and humanised immunotherapy research models, flow cytometry, and IVIS imaging services, the acquisition creates a premier oncology portfolio for the validation of novel cancer therapies.
Low-dose MTE (5 g/kg) significantly enhanced gefitinib efficacy in resistant H460 and HI 975 xenografts
. The combination inhibited tumour proliferation and induced cell apoptosis in both resistant NSCLC xenografts