Development and application of a high-throughput microneutralization assay: lack of xenotropic
murine leukemia virus-related virus and/or murine leukemia virus detection in blood donors.
There are four causal genes identified so far, including solute carrier family 20 member 2 ( SLC20A2 ), platelet-derived growth factor receptor beta ( PDGFRB ), platelet-derived growth factor subunit B ( PDGFB ), xenotropic
and polytropic retrovirus receptor 1 ( XPR1 ). In this study, we reported a familial IBGC pedigree caused by a novel SLC20A2 mutation.
Xenophobic xenophobically, Xenotropic
, xeric, xerographic, xerographically.
Murine Leukemia Virus-related Virus (XMRV)." The Centers for Disease Control and Prevention.
murine leukemia virus-related virus in chronic fatigue syndrome and prostate cancer," Current Allergy and Asthma Reports, vol.
In the wake of the XMRV (xenotropic
murine leukemia virus-related virus) debate, it became a marker of CFIDS.
In 2009, (http://www.sciencemag.org/content/326/5952/585) a paper published in the journal Science linked the disease to a mouse retrovirus called xenotropic
murine leukemia virus-related virus, or XMRV, after finding traces of it in 68 chronic fatigue syndrome patients out of a 101-patient sample.
In addition to being an interesting story about laboratory testing, I recently read that in 2009, researchers in Nevada published data suggesting the patients with chronic fatigue syndrome (CFS) may be infected with xenotropic
murine leukemia virus.
Simple, quantitative assay for both xenotropic
murine leukemia and ecotropic feline leukemia viruses.
While regulations and guidance documents require that virus validations be conducted with relevant viruses as well as specific and non-specific model viruses, a typical panel for biotech/recombinant products would include X-MuLV (xenotropic
Murine Leukemia Virus; retrovirus), HSV (Herpes Simplex Virus)/PRV (Pseudorabies virus), small non-enveloped virus (MMV) and Reovirus.
Two years ago, Vincent Lombardi at the Whittemore Peterson Institute in Reno, Nevada, thought he had found the cause of the tiredness and muscle pain of CFS after discovering a mouse virus called xenotropic
murine leukaemia virus-related virus (XMRV) in blood samples of 68 of 101 people with CFS compared with just eight of 218 samples from healthy volunteers.
Neutralization of mouse xenotropic
virus by lipoproteins involves binding to virons.