zileuton


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zi·leu·ton

 (zī-lo͞o′tn)
n.
A drug that inhibits leukotriene formation, used to treat asthma.

[(ben)z(oth)i(ene), one of its components + leu(ko)t(riene) + -on.]
American Heritage® Dictionary of the English Language, Fifth Edition. Copyright © 2016 by Houghton Mifflin Harcourt Publishing Company. Published by Houghton Mifflin Harcourt Publishing Company. All rights reserved.
References in periodicals archive ?
Concurrent use with medications that are strong inhibitors of CYP3A4 (e.g., clarithromycin, ketoconazole, fluconazole, nelfinavir, zileuton) may increase plasma concentrations and the risk of adverse effects (Tietze, 2017; Woo, 2016).
When polymorphonuclear leukocytes were stimulated by Ca-ionophore, hyperphorin 90 nanoM concentration prevented the formation of 5-lipoxygenase (5-LO) products, and this effect was found to be nearly equivalent to zileuton; also in the same study, when platelets were stimulated by thrombin and ionophore, 0.3 and 3 [micro]M concentrations of hyperphorin inhibited cyclooxygenase (COX)-1, and this inhibition was 3 and 18 times more potent than aspirin, respectively, but the interaction with COX-2, 12-LO, and 15-LO could not be detected (29).
In an RA mouse model, performed in the laboratory of Andrew Luster, the effectiveness of Coversin, which binds to C5 and LTB4, is compared to PAS LTB4-Coversin, which binds to LTB4 alone and to Zileuton, an FDA-approved leukotriene inhibitor.
The researchers administered zileuton, a drug that inhibits leukotriene formation, to mice that had been engineered to develop tau pathology.
Pratico's team gave Zyflo (zileuton) to mice genetically engineered to develop tau tangles .
When the animals were 12 months old, the equivalent of age 60 in humans, they were treated with zileuton, a drug that inhibits leukotriene formation by blocking the 5-lipoxygenase enzyme.
Deoxyhypusine Hydroxylase from Plasmodium vivax, the Neglected Human Malaria Parasite: Molecular Cloning, Expression and Specific Inhibition by the 5-LOX Inhibitor Zileuton. PLoS.
Zileuton [N-(1benzo[b]thien-2-ylethyl)-N- hydroxyure] was obtained from Ono Pharmaceutical (Osaka, Japan) and AA861 from Biomol Research Laboratories (Plymouth Meeting, PA).
Structural modifications which resulted from changes in the ester structure showed significantly improved inhibition of 5-LO when compared to Zileuton (2) [13], the only clinically available 5-LO inhibitor.
A study was carried out by Singh et al., in 2005, which showed that Zileuton, 5-LOX inhibitor and cysteinyl LT receptor antagonists, montelukast, Zafirlukast inhibited the number of writhes in acetic acid-induced writhing method but did not show analgesic activity in tail flick and hot plate methods.
Studies have shown that zileuton, a 5-lipoxygenase inhibitor, has a potent advantageous effect upon pruritus in SLS patients, since it inhibits leukotriene formation [5, 11].