This enzyme was first isolated from human skin in the inactive form, pro-MMP (also called MMP zymogen
), in 1968.
Glycoprotein 2 is excessively glycosylated with N-linked carbohydrates and accounts for almost half of the zymogen
granule membrane proteins in the acinar cells of the pancreas (5).
Trypsin activity began firstly as a zymogen
. Then, to the light of the digestive tract as an active endopeptidase, which cleaves peptide chains mainly in the carboxyl side of lysine and arginine, except when either is followed by proline, releasing smaller peptides and allowing other proteases to perform the hydrolysis process by other parental digestive proteases such as carboxypeptidases and aminopeptidases (Moyano et al, 1996).
CASP-3 is one of the most important mediators of caspases involved in apoptosis, which is found in the cytosol as a zymogen
under normal circumstances.
Its weight and volume were relatively small, the secretion of digestive enzymes was insufficient, the digestion and absorption function was not complete, such as pepsin exists in the state of zymogen
in piglet birth, which can not digest protein, especially vegetable protein.
Tryptase activates thrombin receptors and the zymogen
forms of metalloproteinases (MMPs), including collagenase, gelatinase, and stromelysin, and degrades fibronectin, vitronectin, and neuropeptides, thus promoting arterial dissection and thrombosis.
Caspase is synthesized as an inactive proenzyme (zymogen
) in living cells.
Apices of acinar cells contain zymogen
granules in which are vesicles containing inactive digestive enzymes.
activation and levels of ATP and glutathion eduring caerulein pancreatitis in rats.
Remaining acinar cells were frequently degenerate, characterized by cytoplasmic vacuolation, shrunken angular cellular outlines, and regional depletion of zymogen
The world health organization (WHO) described ACC as a malignant epithelial neoplasm of the salivary glands in which at least few neoplastic cells show serous acinar cell differentiation characterized by cytoplasmic zymogen
Prothrombin or the factor II, a 72 kDa zymogen
precursor of thrombin, consists of 579 amino acids and has a plasma concentration of 2 umol/l.