zymogen


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Related to zymogen: zymogen granules

zy·mo·gen

 (zī′mə-jən)
n.

zymogen

(ˈzaɪməʊˌdʒɛn)
n
(Biochemistry) biochem any of a group of compounds that are inactive precursors of enzymes and are activated by a kinase

zy•mo•gen

(ˈzaɪ mə dʒən, -ˌdʒɛn)

n.
any of various enzyme precursor molecules that may change into an enzyme as a result of catalytic change. Also called proenzyme.
[< German (1875); see zymo-, -gen]
ThesaurusAntonymsRelated WordsSynonymsLegend:
Noun1.zymogen - any of a group of compounds that are inactive precursors of enzymes and require some change (such as the hydrolysis of a fragment that masks an active enzyme) to become active
organic compound - any compound of carbon and another element or a radical
References in periodicals archive ?
This enzyme was first isolated from human skin in the inactive form, pro-MMP (also called MMP zymogen), in 1968.
Glycoprotein 2 is excessively glycosylated with N-linked carbohydrates and accounts for almost half of the zymogen granule membrane proteins in the acinar cells of the pancreas (5).
Trypsin activity began firstly as a zymogen. Then, to the light of the digestive tract as an active endopeptidase, which cleaves peptide chains mainly in the carboxyl side of lysine and arginine, except when either is followed by proline, releasing smaller peptides and allowing other proteases to perform the hydrolysis process by other parental digestive proteases such as carboxypeptidases and aminopeptidases (Moyano et al, 1996).
CASP-3 is one of the most important mediators of caspases involved in apoptosis, which is found in the cytosol as a zymogen under normal circumstances.
Its weight and volume were relatively small, the secretion of digestive enzymes was insufficient, the digestion and absorption function was not complete, such as pepsin exists in the state of zymogen in piglet birth, which can not digest protein, especially vegetable protein.
Tryptase activates thrombin receptors and the zymogen forms of metalloproteinases (MMPs), including collagenase, gelatinase, and stromelysin, and degrades fibronectin, vitronectin, and neuropeptides, thus promoting arterial dissection and thrombosis.
Caspase is synthesized as an inactive proenzyme (zymogen) in living cells.
Apices of acinar cells contain zymogen granules in which are vesicles containing inactive digestive enzymes.
Intrapancreatic zymogen activation and levels of ATP and glutathion eduring caerulein pancreatitis in rats.
Remaining acinar cells were frequently degenerate, characterized by cytoplasmic vacuolation, shrunken angular cellular outlines, and regional depletion of zymogen granules.
The world health organization (WHO) described ACC as a malignant epithelial neoplasm of the salivary glands in which at least few neoplastic cells show serous acinar cell differentiation characterized by cytoplasmic zymogen secretory granules.
Prothrombin or the factor II, a 72 kDa zymogen precursor of thrombin, consists of 579 amino acids and has a plasma concentration of 2 umol/l.