COX-2

(kŏks′to͞o′)

One of two isoenzymes that catalyze the conversion of arachidonic acid into prostaglandins. It is specifically induced at sites of inflammation and can be selectively inhibited by certain NSAIDs in order to reduce pain.

American Heritage® Dictionary of the English Language, Fifth Edition. Copyright © 2016 by Houghton Mifflin Harcourt Publishing Company. Published by Houghton Mifflin Harcourt Publishing Company. All rights reserved.

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Noun

Cox-2 - an enzyme that makes prostaglandins that cause inflammation and pain and fever; "the beneficial effects of NSAIDs result from their ability to block Cox-2"

cyclooxygenase-2

Cox, cyclooxygenase - either of two related enzymes that control the production of prostaglandins and are blocked by aspirin

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References in periodicals archive

The selective COX-2 inhibitors are known to be associated with an increased risk of death in patients with previous MI.[sup][2] In the present case, the prothrombotic effect of a selective COX-2 inhibitor might not be the main pathophysiology of MI.

A Case of Acute Myocardial Infarction Induced by Selective Cyclooxygenase-2 Inhibitor

In addition, correlations between miR-142-3p and Cox-2 as well as PI3K/AKT/mTOR pathways were detected to reveal the underling molecular mechanism in which miR-142-3p protected MLE-12 cells from bleomycin.

microRNA-142-3p inhibits apoptosis and inflammation induced by bleomycin through down-regulation of Cox-2 in MLE-12 cells

COX-2 is an inducible enzyme and produces prostaglandins in response to inflammatory stimulus or growth factors.

Cyclooxygenase-2 expression in colorectal cancer in north India--a pilot study

COX-2 promotes cell migration and dissemination by angiogenesis.

Histologic correlation of VEGF and COX-2 expression with tumor size in squamous cell carcinoma of the larynx and hypopharynx

Enter COX-2. In the late 1990s, the first COX-2 selective NSAID was introduced, to inhibit inflammation-promoting COX-2.

Celecoxib scores ok on cardiac safety: a three-drug, 10-year trial found it equivalent, or "noninferior," to ibuprofen and naproxen

We subsequently investigated whether MK801 (a NMDA receptor inhibitor), Dickkopf-1 (DKK-1, an inhibitor of the Wnt/[beta]-catenin pathway), NS-398 (a COX-2 inhibitor), and bevacizumab (IVB, a VEGF inhibitor) can modulate [beta]-catenin, COX-2, and VEGF expression levels and the neuronal loss in the retinas of the rats.

The Involvement of [beta]-Catenin/COX-2/VEGF Axis in NMDA-Caused Retinopathy

While remaining mammary tumors showed positive behavior of COX-2 gene expression, but it was down regulated as compared to normal samples included in the study with fold changes i.e.

Feline Mammary Tumors Show Altered COX-2 and BRCA1 Expression

Objective: To investigate the effects of varying Warfarin doses on IL-6 and COX-2.

EFFECTS OF DIFFERENT WARFARIN DOSES ON IL-6 AND COX-2 LEVELS

This scientific communication has the goal to report COX-2 expression in seven canine epithelial neoplasms and adjuvant treatment with selective COX-2 inhibitors.

Cyclooxygenase-2 expression in epithelial neoplasms and its relevance as a targeted therapy in dogs/Expressao de ciclooxigenase-2 em neoplasias epiteliais e sua relevancia como terapia alvo em caes

BRCA1 high grade negative expression and COX-2 positive gene expression were observed in this study.

COX-2 AND BRCA1 HAVE ALTERED EXPRESSION PROFILE IN DIFFERENT CANINE TUMORS

All the samples were subjected to immunohistochemical assay to detect the expressions of COX-2, GLUT-1 and VEGF.

Clinical significance of COX-2, GLUT-1 and VEGF expressions in endometrial cancer tissues

A recent analysis, published in the journal Rheumatology, found that the use of COX-2 inhibitors more than doubles the risk of venous thromboembolism (VTE)--the development of a blood clot in a deep vein that may then travels to the lung and form a pulmonary embolism.

NSAIDs may raise risk of blood clots developing in deep veins: COX-2 inhibitors are associated with venous thromboembolisms, but experts say use of the painkillers should be looked at on a case-by-case basis