Almost all (8/9) animals with terminal disease had mild, mixed inflammation composed of heterophils and lymphocytes at the peripheral cornea, as well as mild peripheral corneal neovascularization (representative animal Jos-4; Figure 3, panels A-C); 4 of these animals had a small amount of associated necrotic nuclear debris (Figure 3, panel C).
One study showed that TQ had an inhibitory effect comparable to corticosteroids in a rat model of corneal neovascularization. (8) This inhibition was dose-dependent and its mechanism, although not exactly known, may arise through antioxidant, anti-inflammatory, and immune regulatory factors.
Animal experimental studies revealed that ROCK inhibitors, fasudil and AMA0526, inhibited corneal neovascularization and opacity and facilitated corneal epithelial regeneration after corneal alkali burn [26, 27].
Global Markets Direct's, 'Corneal Neovascularization - Pipeline Review, H1 2016', provides an overview of the Corneal Neovascularization pipeline landscape.
Han and Zhang [sup][18] showed that Robo1 mediate inhibitory effect on corneal neovascularization. However, there was also evidence that Robo1 was pro-angiogenic.
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