Creutzfeldt-Jakob disease

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Creutz·feldt-Ja·kob disease

 (kroits′fĕlt-yä′kôp)
n. Abbr. CJD
A fatal degenerative disease of the brain, caused by a prion and marked by progressive dementia and gradual loss of muscle control. Also called Jakob-Creutzfeldt disease.

[After Hans G. Creutzfeld (1883-1964) and Alfons M., Jakob (1884-1931), German psychiatrists.]
American Heritage® Dictionary of the English Language, Fifth Edition. Copyright © 2016 by Houghton Mifflin Harcourt Publishing Company. Published by Houghton Mifflin Harcourt Publishing Company. All rights reserved.

Creutzfeldt-Jakob disease

(ˈkrɔɪtsfɛlt ˈjɑːkɒp)
n
(Pathology) pathol a fatal slow-developing disease that affects the central nervous system, characterized by mental deterioration and loss of coordination of the limbs. It is thought to be caused by an abnormal prion protein in the brain
[C20: named after Hans G. Creutzfeldt (1885–1964) and Alfons Jakob (1884–1931), German physicians]
Collins English Dictionary – Complete and Unabridged, 12th Edition 2014 © HarperCollins Publishers 1991, 1994, 1998, 2000, 2003, 2006, 2007, 2009, 2011, 2014

Creutz′feldt-Ja′kob disease`

(ˈkrɔɪts fɛltˈyɑ kɔp)
n.
a fatal degenerative disease of the human brain, thought to be caused by an abnormal, infectious form of cellular prion protein.
[1965–70; after German physicians Hans German. Creutzfeldt (1885–1964) and Alfons Jakob (1884–1931)]
Random House Kernerman Webster's College Dictionary, © 2010 K Dictionaries Ltd. Copyright 2005, 1997, 1991 by Random House, Inc. All rights reserved.
ThesaurusAntonymsRelated WordsSynonymsLegend:
Noun1.Creutzfeldt-Jakob disease - rare (usually fatal) brain disease (usually in middle age) caused by an unidentified slow virus; characterized by progressive dementia and gradual loss of muscle control
brain disease, brain disorder, encephalopathy - any disorder or disease of the brain
Based on WordNet 3.0, Farlex clipart collection. © 2003-2012 Princeton University, Farlex Inc.
Translations

Creutzfeldt-Jakob disease

Collins German Dictionary – Complete and Unabridged 7th Edition 2005. © William Collins Sons & Co. Ltd. 1980 © HarperCollins Publishers 1991, 1997, 1999, 2004, 2005, 2007
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References in periodicals archive
BOSTON -- Regional brain changes measured by magnetic resonance diffusion weighted imaging can be detected a decade or more before the onset of symptoms of Creutzfeldt-Jakob disease, according to Isak Prohovnik, Ph.D., who presented his findings at the annual meeting of the American Academy of Neurology.
''I don't know if it's appropriate for me to say it this way, but Creutzfeldt-Jakob Disease is a fatal disease and in like fashion I want to eliminate such media reports,'' he said.
Pathologist Dr Martin Carey told an inquest in Walsall that the provisional cause of death was acute pyelitis - inflamation of part of the kidney - and new variant Creutzfeldt-Jakob Disease.
Prusiner was stimulated in his investigations when, as a resident in Neurology in 1972, he cared for a 62-year-old patient who died of Creutzfeldt-Jakob disease. The disease was then thought to be caused by a slow virus.
Six months later, when he couldn't recognize his closest friends, neurologists took a biopsy of his brain, and gave him the diagnosis: Creutzfeldt-Jakob Disease (CJD).
One Creutzfeldt-Jakob Disease sufferer is still alive.
"At least one in every million people gets Creutzfeldt-Jakob Disease (CJD) each year," says Ermias Belay, an epidemiologist and CJD expert with the Centers for Disease Control and Prevention (CDC) in Atlanta.
Caption: (L-R) Hans Gerhard Creutzfeldt (18851964); Alfons Maria Jakob (1884-1931); Creutzfeldt-Jakob disease, cerebrum hematoxylin and eosin staining showing spongiform encephalophathy.
But as this documentary looking back at the scandal points out, we are still living with the aftermath in the form of Variant Creutzfeldt-Jakob disease (VCJD), which has killed almost 200 people since 1996.
Here we report the case of a patient who had been treated, but after clinical evaluation demonstrated to be a case of sporadic Creutzfeldt-Jakob disease (sCJD), a rare and fatal neurodegenerative condition.
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