ki·nase

(kī′nās′, -nāz′, kĭn′ās′, -āz′)

Any of various enzymes that catalyze the transfer of a phosphate group from a donor, such as ADP or ATP, to an acceptor protein. Kinases regulate many essential cellular processes.

[kin(etic) + -ase.]

American Heritage® Dictionary of the English Language, Fifth Edition. Copyright © 2016 by Houghton Mifflin Harcourt Publishing Company. Published by Houghton Mifflin Harcourt Publishing Company. All rights reserved.

kinase

(ˈkaɪneɪz; ˈkɪn-)

1. (Biochemistry) any enzyme that can convert an inactive zymogen to the corresponding enzyme

2. (Biochemistry) any enzyme that brings about the phosphorylation of a molecule

[C20: from kin(etic) + -ase]

Collins English Dictionary – Complete and Unabridged, 12th Edition 2014 © HarperCollins Publishers 1991, 1994, 1998, 2000, 2003, 2006, 2007, 2009, 2011, 2014

ki•nase

(ˈkaɪ neɪs, -neɪz, ˈkɪn eɪs, -eɪz)

n.

an enzyme that effects the transfer of a phosphate group from ATP to another molecule.

[1900–05; kin (etic) + -ase]

ThesaurusAntonymsRelated WordsSynonymsLegend:

Noun

kinase - an enzyme that catalyzes the conversion of a proenzyme to an active enzyme

enzyme - any of several complex proteins that are produced by cells and act as catalysts in specific biochemical reactions

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References in periodicals archive

Candidate target genes of hsa-miR-424-5p and hsa-miR-377 Gene name Main pathway Target Accession gene ID hsa-miR-424-5p Hypoxia and angiogenesis HIF1A MIRT005926 CUL2 MIRT005927 Cell cycle CDK6 MIRT000938 CCND1 MIRT000941 CCNE1 MIRT000936 CCND3 MIRT000937 hsa-miR-377 MAPK pathway PPM1A MIRT000990 PI3K-akt pathway PAK1 MIRT000991 HIF1A: Hypoxia-inducible factor 1A; CUL2: Cullin 2; CDK: Cyclin-dependent kinase; CCND1: Cyclin D1; CCNE1: Cyclin E1; CCND3: Cyclin D3; MAPK: Mitogen-activated protein kinase; PPM1A: Protein phosphatase magnesium-dependent 1A; PI3K: Phosphatidyl inositol 3'-kinase; PAK1: p21-activated kinase 1.

Micro-ribonucleic acid profiles from microarray in ankylosing spondylitis

Targeting cyclins and cyclin-dependent kinases in cancer: lessons from mice, hopes for therapeutic applications in human.

The involvement of cyclin D1 degradation through GSK3[beta]-mediated threonine-286 phosphorylation-dependent nuclear export in anti-cancer activity of mulberry root bark extracts

This is typical of cyclin-dependent kinase family, of which Cdk5 is a member.

Cdk5r1 overexpression induces primary [beta]-cell proliferation

Rossi, "Cyclin-dependent kinase inhibitor drugs as potential novel anti-inflammatory and pro-resolution agents," British Journal of Pharmacology, vol.

Switching off key signaling survival molecules to switch on the resolution of inflammation

Shapiro, "Cyclin-dependent kinase pathways as targets for cancer treatment," Journal of Clinical Oncology, vol.

Assessment of the potential of CDK2 inhibitor NU6140 to influence the expression of pluripotency markers NANOG, OCT4, and SOX2 in 2102Ep and H9 cells

Ruiling Zhang and team from Xinxiang Medical University explored the correlation between cyclin-dependent kinase 5 expression in the hippocampus and neurological impairments following prenatal ethanol exposure, and found that prenatal ethanol exposure could affect cyclin-dependent kinase 5 and its activator p35 in the hippocampus of offspring rats.

Alcohol consumption during pregnancy affects fetus' nervous system

Involvement of the cyclin-dependent kinase inhibitor p16 (INK4a) in replicative senescence of normal human fibroblasts.

Electrophoretical mobility of nuclei in buccal cells of cystic fibrosis patients

Hermanetal., "Interplay between cyclin-dependent kinase 5 and glycogen synthase kinase 3[beta] mediated by neuregulin signaling leads to differential effects on tau phosphorylation and amyloid precursor protein processing, " Journal of Neuroscience, vol.

The beta-amyloid protein of Alzheimer's disease: communication breakdown by modifying the neuronal cytoskeleton

(6.) Echalier A, Endicott JA, Noble ME: Recent developments in cyclin-dependent kinase biochemical and structural studies.

Flow cytometric evaluation of cell cycle regulators (cyclins and cyclin-dependent kinase inhibitors) expressed on bone marrow cells in patients with chronic myeloid leukemia and multiple myeloma / Kronik Miyelositer Losemi ve Multipl Miyelom Olgularmdaki Kemik Iligi Kaynakh Hucrelerde, Hucre Siklusu Duzenleyicilerinin (Siklinler ve Siklin Bagimli Kinaz Inhibitorleri) Alum Sitometrik Olarak Degerlendirilmesi

p15, one member of the cyclin-dependent kinase inhibitors (CDKIs) family, can prevent transition from the G1 to S phase by inhibiting CDK4/6-cyclinD mediated phosphorylation of retinoblastoma (Rb) [8].

Silence of p15 expression by RNAi enhances cisplatin resistance in hepatocellular carcinoma cells

Real-time RT-PCR demonstrated that the expression of the cell cycle-driving molecule, cyclin-dependent kinase 4 (Cdk4), in HCC was significantly reduced by the treatments with vitamin K2, K3 and K5.

Journal abstracts: vitamins K2, K3 and K5 exert in vivo antitumor effects on hepatocellular carcinoma by regulating the expression of G1 phase-related cell cycle molecules