mast cell

A cell produced in bone marrow that functions in allergic reactions and other inflammatory and immune responses by releasing substances such as histamine and cytokines and by directly killing pathogens. Mast cells are found chiefly in connective tissue and contain basophilic granules.

[Partial translation of German Mastzelle, well-fed cell (from an early view that the granules were from phagocytosis) : Mast, food, mast (from Middle High German, from Old High German) + Zelle, cell.]

American Heritage® Dictionary of the English Language, Fifth Edition. Copyright © 2016 by Houghton Mifflin Harcourt Publishing Company. Published by Houghton Mifflin Harcourt Publishing Company. All rights reserved.

mast cell

(Biology) a type of granular basophil cell in connective tissue that releases heparin, histamine, and serotonin during inflammation and allergic reactions

[C19: from mast², on the model of German Mastzelle]

Collins English Dictionary – Complete and Unabridged, 12th Edition 2014 © HarperCollins Publishers 1991, 1994, 1998, 2000, 2003, 2006, 2007, 2009, 2011, 2014

mast′ cell`

a large granular cell, common in connective tissue, that produces heparin, histamine, and serotonin.

[1885–90; partial translation of German Mastzelle=Mast mast² + Zelle cell]

ThesaurusAntonymsRelated WordsSynonymsLegend:

Noun

mast cell - a large connective tissue cell that contains histamine and heparin and serotonin which are released in allergic reactions or in response to injury or inflammation

labrocyte, mastocyte

connective tissue - tissue of mesodermal origin consisting of e.g. collagen fibroblasts and fatty cells; supports organs and fills spaces between them and forms tendons and ligaments

somatic cell, vegetative cell - any of the cells of a plant or animal except the reproductive cells; a cell that does not participate in the production of gametes; "somatic cells are produced from preexisting cells";

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References in periodicals archive

Church, "Human mast cell heterogeneity: histamine release from mast cells dispersed from skin, lung, adenoids, tonsils, and colon in response to IgE-dependent and nonimmunologic stimuli," The Journal of Allergy and Clinical Immunology, vol.

Development of Human Mast Cells from Hematopoietic Stem Cells within a 3D Collagen Matrix: Effect of Stem Cell Media on Mast Cell Generation

Our study revealed that mast cell count is increased in OLP compared to OLR thereby guiding us to propose that mast cell count can be used as one of the essential histopathological elements in the differentiation of OLP and OLR.

Role of Mast Cells in Oral Lichen Planus and Oral Lichenoid Reactions

To confirm that the protective effects of mast cell engraftment were not a result of supplying IL10 derived from engrafted WT BMMCs, we also assessed colitis in DKO mice engrafted with [IL10.sup.-/-] BMMCs (derived from [IL10.sup.-/-] mice).

Mast Cells Exert Anti-Inflammatory Effects in an [IL10.sup.-/-] Model of Spontaneous Colitis

This is especially true with mast cell tumors, which can be found within lipomas (a mast cell is an immune cell found in connective tissue; see sidebar).

A Lipoma Is a Common Lump: But get it checked--mast cells may lurk inside

Similarly, canine mast cell tumor is the most common neoplasm, representing 7 to 25% and 11 to 27% of all skin tumors and malignant skin tumors in dogs (Bostocket al., 1973).

MOLECULAR EXPRESSION OF CYCLIN DEPENDENT KINASE INHIBITOR (p21) IN CANINE TUMORS

(the 'Company') (Nasdaq: ALLK), a biotechnology company developing AK002 for the treatment of eosinophil and mast cell related diseases, today reported financial results for the second quarter ended June 30, 2019.

Allakos Reports Second Quarter 2019 Financial Results

Treatment focuses on minimizing mast cell degranulation

Multiple hyperpigmented papules and plaques

Raj Patel, MD, and Thalia Farshchian, ND, of Medical Options for Wellness (MOW; http://medicaloptionsforwellness.net) in Foster City, California, have observed clinically how important it has become to evaluate their patients for mast cell activation syndrome (MCAS).

Mast Cell Activation Syndrome: A Key Exploration in Recovering from Chronic Lyme Disease

Avapritinib has received FDA Breakthrough Therapy Designation for the treatment of patients with advanced SM, including the subtypes of aggressive SM, SM with an associated hematologic neoplasm and mast cell leukemia.

Blueprint Medicines presents updated EXPLORER trial data for Avapritinib

Total and granulated mast cell count and biochemical marker levels were analysed with Student's t test.

The Effects of Mobile Phone Exposure on Mast Cells in Rat Dura Mater/Efectos de la Exposicion del Telefono Movil en los Mastocitos de la Duramadre de Ratas

Those of you who have a pet who has had surgery to remove mammary tumours, mast cell tumours or any other type of lump or bump that is excess to requirements will know exactly what I mean.

Vigilance can save a life; RECORD PETS

In the present study, we showed that compound 48/80 induced dural mast cell degranulation leads to vasodilation of middle meningeal artery and its anterior and posterior branches.

Mast Cell Degranulation Mediates Compound 48/80-Induced Meningeal Vasodilatation Underlying Migraine Pain/Mast Hucre Degranulasyonu Compound 48/80 ile Tetiklenmis Migren Agrisinin Altinda Yatan Meningeal Vazodilatasyona Aracilik Ediyor