In refractory cases, leukotriene receptor antagonists or oral
cromolyn sodium may be considered.
RVT-1601is a novel formulation of inhaled
cromolyn sodium delivered through a proprietary nebuliser device designed to yield high lung deposition and distribution, as well as related assets owned by Patara Pharma.
The company said PA101 (RVT-1601) is a novel formulation of inhaled
cromolyn sodium delivered through a proprietary nebulizer device designed to yield high lung deposition and distribution.
In addition, in a mouse model of brain ischemia, animals that were deficient in MCs or treated with the MC stabilizer
Cromolyn exhibited improved BBB integrity and reduced brain edema [70].
An ophthalmology examination showed bilateral lid swelling, diffuse conjunctival redness, and watery discharge (Figure 5), which was treated with topical antihistamines and
cromolyn sodium.
Other possible treatments include topical
cromolyn sodium and leukotriene antagonists.
Nutritional support, systemic glucocorticoids, azathioprine, anabolic steroids, anti-inflammatory (i.e., mesalamine), histamine-receptor antagonists,
cromolyn sodium, and surgical treatment have all been used with varying degrees of success.
Dr Wasim Khawaja said people with seasonal allergies who cannot avoid pollen, the symptoms can be controlled with medication on advice of physician including antihistamines, corticosteroids, and
cromolyn sodium, any of which can be used alone or in combination.
* Intranasal
cromolyn sodium:
Cromolyn sodium (Nasalcrom) is a mast cell stabilizer, so it can prevent the release of inflammatory mediators associated with allergic rhinitis, including the release of histamine.
Cromolyn sodium21 and dexamethasone/prednisolone22 injections have been used for management.
Cromolyn sodium is considered an antiasthmatic, an anti-allergic and a mast cell stabilizer.
In severe cases sodium
cromolyn is the safe treatment for all allergic rhinitis.