These include cromolyn,
nedocromil, leukotriene modifiers, and antihistamines (Woo, 2016).
Long-term effects of budesonide or
nedocromil in children with asthma.
Harness, Adsorption of Water by Anhydrous
Nedocromil Sodium from 20 to 40degC, J.
sodium cromoglycate,
nedocromil sodium, pemirolast, and lodoxamide; (3) Dual acting agents - they have both antihistaminic and mast cell stabilizing properties, e.g., olopatadine, ketotifen, azelastine, and epinastine; (4) Non-steroidal anti-inflammatory drugs, e.g., ketorolac, diclofenac, and flurbiprofen; (5) Corticosteroids, e.g., prednisolone, hydrocortisone, fluorometholone, loteprednol, and desonide.
There are three drugs in this class that can be used topically in the eye: cromolyn, lodoxamide (Alomide), and
nedocromil (Alocril).
Nedocromil sodium exerts its anti-inflammatory and anti-asthmatic effect by inhibiting the activation and activity of multiple inflammatory cells, including mast cells, eosinophils, airway epithelial cells and sensory neurons.
(1) Eleven trials that included 899 children and adults compared mast cell stabilizers (sodium cromoglycate,
nedocromil, and lodoxamide tromethamine) with placebo.
Ozone-induced mediator release from human bronchial epithelial cells in vitro and the influence of
nedocromil sodium.
Drugs, such as sodium cromoglycate,
nedocromil sodium, pemirolast, and lodoxamide act by stabilizing mast cells.
As with VKC, AKC requires long-term therapy with topical mast cell stabilisers such as sodium cromoglycate, lodoxamide and
nedocromil to treat the allergic inflammation in mild cases.
G protein-coupled receptor-35 (GPR35) has been shown to be a target of the asthma drugs cromolyn disodium and
nedocromil sodium.