Gamma secretase cleaves multiple
transmembrane protein complexes, including Notch, which is believed to play a role in activating pathways that contribute to desmoid tumor growth.
Programmed death-ligand 1 (PD-L1) is a
transmembrane protein that plays a major role in suppressing the immune system in many cancer patients.
Programmed death-ligand 1, or PD-L1, is a
transmembrane protein that plays a major role in suppressing the immune system in many cancer patients.
The company stated that CD19 is a
transmembrane protein expressed in B cells and overexpressed in advanced leukemia and lymphoma representing a well validated therapeutic target.
Grail is a type I
transmembrane protein localized in the transferrin-recycling endocytic pathway, and it plays a crucial role on the induction of anergy by abrogating the expression of cytokines in T cells.[1] A recent study has shown that Grail forms a ternary complex with Otub-1 and USP8, which regulates T cell anergy.[2],[3] Recently, a number of proteins were identified to be associated with Grail.
An improved hidden Markov model for
transmembrane protein detection and topology prediction and its applications to complete genomes.
The first identified member of the ALMT family (Aluminum-activated malate transporter) was TaALMT1, discovered in the tips of the roots of wheat expressing a constitutively expressed
transmembrane protein (SASAKI et al., 2004).
"Despite anatomical differences between octopus and human brain, we've shown that there are molecular similarities in the serotonin transporter gene," said Gul Dolen, noting that the gene encodes a
transmembrane protein that serves as the primary binding site for MDMA.
The closest protein-coding genes to rs6759298 are B3GNT2 genes (UDP-GlcNAc: betaGal beta-l,3-N acetylglucosaminyltransferase) which codify for a type II
transmembrane protein involved in the biosynthesis of poly-N-acetyllactosamine chains, COMMD1 (copper metabolism domain containing, coding a regulator of copper homeostasis, sodium uptake, and NF-kappa-B signaling, and finally TMEM17 (
transmembrane protein 17), coding a transmembrane component of a complex, which is required for ciliogenesis and sonic hedgehog/SHH signaling (20,22).
Predicting
transmembrane protein topology with a hidden Markov model: application to complete genomes.
CD22 is a B-lymphocyte restricted
transmembrane protein with a higher receptor density in HCL cells relative to normal B cells, making it an attractive therapeutic target for the treatment of this cancer.