tumor necrosis factor

Abbr. TNF Any of a family of small transmembrane proteins that can be released as soluble cytokines, are produced especially by monocytes and macrophages, and perform a variety of functions including activating inflammatory processes and causing cell death.

American Heritage® Dictionary of the English Language, Fifth Edition. Copyright © 2016 by Houghton Mifflin Harcourt Publishing Company. Published by Houghton Mifflin Harcourt Publishing Company. All rights reserved.

tu′mor necro`sis fac`tor

a protein, produced in humans and other animals, that is destructive to cells showing abnormally rapid growth. Abbr.: TNF

[1985–90]

ThesaurusAntonymsRelated WordsSynonymsLegend:

Noun

tumor necrosis factor - a proinflammatory cytokine that is produced by white blood cells (monocytes and macrophages); has an antineoplastic effect but causes inflammation (as in rheumatoid arthritis)

TNF, tumour necrosis factor

cytokine - any of various protein molecules secreted by cells of the immune system that serve to regulate the immune system

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References in periodicals archive

The silent progression of metastatic malignancy during the treatment with soluble tumor necrosis factor receptor.

Cervix cancer in a patient with ankylosing spondylitis using etanercept: a case report/Etanercept kullanan ankilozan spondilitli hastada serviks kanseri: bir olgu sunumu

Jack Lichtenstein noted that he had observed that several of his patients receiving tumor necrosis factor (TNF) inhibitors developed severe methicillin-resistant S.

MRSA infections are seen in patients on anti-TNF therapy

Polymorphism at position -308 of the tumor necrosis factor alpha gene influences outcome of infliximab therapy in rheumatoid arthritis.

Predicting response to TNF antagonists in rheumatoid arthritis: the promise of pharmacogenetics research using clinical registries

Tumor necrosis factor production by monocytes infiltrating atherosclerotic lesions is a key factor in the genesis and progression of vascular damage, and oxidative stress of the vascular wall sustained by circulating activated PMNs is an early step in the cascade leading to cardiovascular pathology in otherwise asymptomatic individuals.

HMRlignan provides cardiovascular protection

Effects of a polymorphism in the human tumor necrosis factor [alpha] promoter on transcriptional activation.

Rapid genotyping for tumor necrosis factor-[alpha] (TNF-[alpha]) -863C/A promoter polymorphism that determines TNF-[alpha] response

Cerami, "Tumor necrosis factor: a pleiotropic cytokine and therapeutic target," Annual Review of Medicine, vol.

Interaction of dietary fatty acids with tumour necrosis factor family cytokines during colon inflammation and cancer

The supplemental approval comes a year after the FDA approved tocilizumab, an interleukin-6 receptor inhibitor for the treatment of adults with moderately to severely active RA who have had an inadequate response to one or more tumor necrosis factor antagonist therapies.

Tocilizumab's indications expanded

The medical records of more than 5,000 patients were evaluated over a five-year period to assess the risk of bacterial infection among those who use drugs that inhibit tumor necrosis factor (TNF).

Some RA drugs increase shingles risk

enumerate the multiple, distinct receptor homologs and binding proteins encoded by poxviruses that target tumor necrosis factor. L.K.

Molecular Pathogenesis of Virus Infections

(Rockville, MD) and University of Michigan (Ann Arbor, MI) have patented Death Domain Containing Receptor (DR3 and DR3-V1) proteins which are members of the tumor necrosis factor receptor family.

Human Genome Sciences obtains United States patent

As the body lurches into a self-defense mode, it mass-produces inflammatory proteins, such as tumor necrosis factor alpha (TNF-alpha) and high-mobility group box 1 (HMGB1).

Inhibiting immune compound slows sepsis