alkylating agent

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alkylating agent

(ˈælkɪˌleɪtɪŋ)
n
(Pharmacology) any cytotoxic drug containing alkyl groups, such as chlorambucil, that acts by damaging DNA; widely used in chemotherapy
Collins English Dictionary – Complete and Unabridged, 12th Edition 2014 © HarperCollins Publishers 1991, 1994, 1998, 2000, 2003, 2006, 2007, 2009, 2011, 2014
ThesaurusAntonymsRelated WordsSynonymsLegend:
Noun1.alkylating agent - an antineoplastic drug used to treat some forms of cancer
antineoplastic, antineoplastic drug, cancer drug - any of several drugs that control or kill neoplastic cells; used in chemotherapy to kill cancer cells; all have unpleasant side effects that may include nausea and vomiting and hair loss and suppression of bone marrow function
chlorambucil, Leukeran - an alkalating agent (trade name Leukeran) used to treat some kinds of cancer
Based on WordNet 3.0, Farlex clipart collection. © 2003-2012 Princeton University, Farlex Inc.
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References in periodicals archive
Chlorooctane is also used as an alkylating agent in organosynthesis, organometallic compound manufacturing, and as a solvent.
Chlorooctane Market Anticipated to Achieve High CAGR Percentages during 2018-2028
Several studies have revealed that chemotherapy medications used mostly in patients with haematological malignancy were alkylating agents, anti-metabolites, vinca alkaloids, and the patients experienced more grade 2 mucositis.20 It was determined in the present study that most of the patients received alkylating agent therapy had grade 0 and grade 1 mucositis.
The effect of three different solutions on preventing oral mucositis in cancer patients undergoing stem cell transplantation: a non-randomized controlled trial: A Turkish study
The company said OBI-3424 is a first-in-class novel small-molecule prodrug that selectively targets cancers overexpressing the enzyme aldo-keto reductase 1C3 (AKR1C3), and selectively releases a potent DNA alkylating agent in the presence of the AKR1C3 enzyme.
OBI Pharma Inc wins US FDA's orphan drug designation for OBI-3424 for Acute Lymphoblastic Leukemia
Elias et al., "High-dose combination alkylating agent preparative regimen with autologous bone marrow support: The Dana-Farber Cancer Institute/Beth Israel Hospital experience," Cancer Treatment Reports, vol.
Development of Focal Nodular Hyperplasia after Cyclophosphamide-Based Chemotherapy in a Patient with Breast Cancer
The most commonly implicated alkylating agent for the development of SOS is busulfan.
Sinusoidal Obstruction Syndrome (SOS) in Multiple Myeloma with Renal Failure
MMS, an alkylating agent, is known for its ability to interact with DNA in vitro and in vivo producing genotoxic damage.
GENOTOXIC, ANTIGENOTOXIC AND PROTECTIVE EVALUATION OF TINOSPORA CORDIFOLIA STEM BY PERIPHERAL BLOOD MICRONUCLEUS ASSAY
Summary: Pyrroloimidazoles have been synthesized by diastereoselective of 1,3-dipolar cycloaddition by using 4, 5-dihydroimidazolium ylides with an alkylating agent and base.
New Pyrroloimidazoles by 1, 3-Dipolar Cycloaddition and their Biological Activities
Although there are a variety of articles about phase-transfer catalysts, little has been reported about them as an alkylating agent of nitrogen heterocyclic rings [5].
A Novel and Chemoselective Process of N-Alkylation of Aromatic Nitrogen Compounds Using Quaternary Ammonium Salts as Starting Material
Therapy-related acute leukemias in general have been attributed to topoisomerase II inhibitors and alkylating agents. (1) Patients with therapy-related acute leukemias from alkylating agents generally show a latency of 3-7 years from exposure to the alkylating agent and often have an insidious course, with the development of MDS prior.
Therapy-related T/myeloid mixed phenotype acute leukemia in a patient treated with chemotherapy for cutaneous diffuse large B cell lymphoma
It is a bifunctional alkylating agent and one of the most aggressive antineoplastic drugs indicated for multiple myeloma and ovarian cancer [1].
Protective effect of quercetin on Melphalan-induced oxidative stress and impaired renal and hepatic functions in rat
Each wafer contains the nitrosourea alkylating agent carmustine distributed in a biodegradable polymer matrix.
Eisai to Receive Japan Marketing Authorization Holder License from Nobelpharma for Antineoplastic Agent Gliadel 7.7mg Implant
The alkylating agent ethylmethanesulphonate (EMS) (CAS, 62-50-0) was purchased from Sigma Chemical Company (Saint Louis, MO.
Protective activity of Cynara scolymus L. leaf extract against chemically induced complex genomic alterations in CHO cells
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