Scientists now have used stem cell technology to successfully create melanocyte precursor cells that can be used in research on melanoma and other pigment cell-related illnesses.
"Scientists have long known that in order to prevent hair from going grey they would need to either prolong the life of the melanocytes in the hair bulb -- by protecting them from injury -- or expand the melanocyte stem cell reservoir in the upper or top region of the hair follicle so they continue to replace lost pigment cells,"explainedRodney Sinclair, Professor of Dermatology, Epworth Hospital, at the University of Melbourne.
Harris said melanocyte stem cells were essential to hair color as they produced the melanocytes that were responsible for making and depositing pigment into the hair shaft.
The origin of the melanoma precursor cell is open to debate, but it is most probably a tissue-specific stem/progenitor melanocyte that over time has acquired cytogenetic and epigenetic alterations and has ultimately undergone malignant transformation.
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