melphalan

(ˈmɛlfəˌlæn)

(Pharmacology) a drug, C13H18Cl2N2O2, used to treat myeloid leukaemia

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Noun

melphalan - antineoplastic drug (trade name Alkeran) used to treat multiple myeloma and some other malignancies

Alkeran

antineoplastic, antineoplastic drug, cancer drug - any of several drugs that control or kill neoplastic cells; used in chemotherapy to kill cancer cells; all have unpleasant side effects that may include nausea and vomiting and hair loss and suppression of bone marrow function

Translations

melphalan

n melfalán m

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References in periodicals archive

Melphalan is already being used in the clinical setting in the form of intra-arterial delivery and intravitreal injections for treatment of retinoblastoma, and preliminary studies have shown promise [14].

Intravitreal and subconjunctival melphalan for retinoblastoma in transgenic mice

Treatment of AL amyloidosis with high-dose melphalan and stem cell transplantation has proven effective, with a sustained clinical response and reversal of amyloid-related organ dysfunction.

Progressive renal light chain amyloidosis with the absence of detectable free monoclonal light chains after an autologous hematopoietic stem cell transplant for amyloid light chain amyloidosis

Alkylating agents like melphalan should be avoided as these are damaging to stem cells and will make it difficult to collect stem cell for transplant later.

Multiple myeloma: an update

Isolated hepatic perfusion with high-dose melphalan results in immediate alterations in tumor gene expression in patients with metastatic ocular melanoma.

Chemotherapy to the liver delays progression of metastatic melanoma

High-dose melphalan (140-200 mg/[m.sup.2]) and autologous peripheral blood stem-cell transplantation is considered the most effective treatment of AL amyloidosis.

Amyloid light-chain amyloidosis, myeloma and autonomic neuropathy

In this report, we describe a case of primary AL amyloidosis in a young patient with isolated kidney involvement and rapid progression to ESRD, treated successfully with melphalan and ASCT.

Primary amyloidosis of the kidney

It also can reduce mucositis associated with high-dose melphalan, Dr.

Oral hygiene important for preventing oral mucositis

"Thalidomide is available in the United States, Australia, New Zealand and elsewhere now, and we would like all patients to have safe access to its demonstrated benefits." The combination of melphalan and prednisone (MP) was once the standard of care for myeloma in Europe, but recent studies have shown the combination is greatly improved by the addition of the Novel Therapies: This positive opinion for thalidomide MP is based on a multi-center clinical trial showing average survival of more than 4 years, a year and a half more than MP without thalidomide.

MYELOMA TREATMENT FOR OLDER PATIENTS SET FOR APPROVAL

Those given standard therapy of the drugs melphalan and prednisone plus thalidomide survived an average of 51.6 months.

Thalidomide can help treat cancer

For over 30 years no therapy was superior to oral melphalan and prednisone (MP).

The approach to the management of multiple myeloma has changed over the past decade

In addition, intermediate doses of melphalan, a potent chemotherapy drug commonly used in multiple myeloma, may provide equivalent activity and less toxicity than does high-dose therapy.

Multiple myeloma responds to new regimens