Also, results from open-label studies and one randomized, placebo-controlled study suggest that treatment of CD patients with
sargramostim (Leukine[R], Berlex, New Jersey), a yeast-derived recombinant human granulocyte-macrophage colony-stimulating factor, may attenuate severity of the disease, promote overall improvement and, in some cases, may induce disease remission (11-14).
Comparison of
sargramostim and filgrastim in the treatment of chemotherapy-induced neutropenia.
An earlier study examined patient satisfaction in both patients receiving long-acting growth factors (darbepoetin alfa, pegfilgrastim) or short-acting growth factors (
sargramostim, epoetin alfa) in the oncology setting (Beveridge et al., 2003), in which patients were neutral concerning satisfaction with their current regimen.
CSFs include granulocyte -colony-stimulating factors, such as filgrastim (Neupogen[R], Amgen Inc., Thousand Oaks, CA), and granulocyte -macrophage colony-stimulating factors, such as
sargramostim (Leukine[R], Berlex Laboratories, Montville, NJ).
HONOLULU --
Sargramostim shows considerable promise as a novel treatment for Crohn's disease, Dr.
Filigastrim (Neupogen[R]) and
sargramostim (Leukine[R]) are used to enhance the WBC count (Pagana & Pagana, 2002).
Current recommendations call for treating disseminated trichosporonosis with an azole, along with granulocyte-macrophage colony-stimulating factor (
sargramostim), said Dr.
In the new agreement, AHP has agreed to return to Immunex the ex-North american rights to Leukine (
sargramostim), Mobist (FLT-3 ligand) and Interleukin-15 (IL-15).
Partner Therapeutics, an integrated oncology company, has received rights from France-based Sanofi to develop, manufacture and commercialise Leukine (
sargramostim), it was reported on Friday.
COPENHAGEN -- Daily treatment with
sargramostim led to significantly improved quality of life in patients with moderate to severe Crohn's disease in a study with 124 patients.
Therapy with GM-CSF (
sargramostim, trade names Leukine[R], Proline[R]) has been associated with an increase in circulating neutrophils, eosinophils and, to a small extent, lymphocytes (Scadden, 1997).