Therefore, we are now working on research to analyze the function of secretases and invent a medicine to prevent it or discover a therapy to eliminate the
senile plaque by using antibodies to amyloid.
Chronic inflammation can lead to weakening of the blood-brain barrier in older adults, which allows microbes or pathogens to enter the brain, triggering AD-related
senile plaque pathology and yet more inflammation.
Enhanced oxidative stress leads to deposition of
senile plaque and synaptic loss that result in neurodegeneration.
A[beta], [beta]-amyloid; AD, Alzheimer's disease; ATP, adenosine triphosphate; CAD, Cath.a differentiated; iNOS, inducible nitric oxide synthase; IR, infrared; IR1068, infrared at 1068 nm; LDH, lactate dehydrogenase; LILT, Low-Intensity Light Therapy; MMP+, 1methly-4- phenylpyridium; NIR, near-infrared; SP,
senile plaque; UVA, ultra violet A.
Rivest, "Bone marrow-derived microglia play a critical role in restricting
senile plaque formation in Alzheimer's disease," Neuron, vol.
Another paper entitled "Confocal observation of
senile plaques in Alzheimer's disease:
senile plaque morphology and relationship between
senile plaques and astrocytes" was published by Kato et al.
This study compares the
senile plaque burden in control and Alzheimer brains within the superior temporal cortex with the expression of blood-brain barrier endothelial proteins associated with the transfer and transport of amyloid (Table 1).
Beta-amyloid deposits are present at autopsy in about 40% of individuals with CTE, but they are very different from the
senile plaque type of beta-amyloid deposits that are a hallmark of Alzheimer's disease.
Neuropathology topics include cellular prion protein signaling, triggers of
senile plaque, preservation of mitochondria volume in age, the role of selenite on microglial migration, intensive remodeling of Parkinje cell spines, and activation and endocytic internalization of melanocortin 3 receptors in neuronal cells.
Exciting applications of PET technology," include measuring therapeutic drug effects and assessing
senile plaque burden.
Firstly, the antibodies would bind directly to the peptides in the
senile plaque, destabilizing the interactions of the A[beta] molecule and disrupting them (18).
(1-42) is the principal species associated with
senile plaque amyloids, while A?
amyloid plaque - a plaque consisting of tangles of amyloid protein in nervous tissue (a pathological mark of Alzheimer's disease)