tissue plasminogen activator

n. Abbr. tPA or TPA

1. A clot-dissolving enzyme that is produced naturally by cells in the walls of blood vessels and catalyzes the conversion of plasminogen to plasmin.

2. A preparation of this enzyme that is produced by genetic engineering and is used as a drug to dissolve blood clots in the immediate treatment of certain cases of stroke and heart attack.

American Heritage® Dictionary of the English Language, Fifth Edition. Copyright © 2016 by Houghton Mifflin Harcourt Publishing Company. Published by Houghton Mifflin Harcourt Publishing Company. All rights reserved.

TPA

or tPA,

tissue plasminogen activator: an anticlotting enzyme of the blood, produced in quantity by genetic engineering for use in dissolving blood clots.

ThesaurusAntonymsRelated WordsSynonymsLegend:

Noun

tissue plasminogen activator - a thrombolytic agent (trade name Activase) that causes fibrinolysis at the site of a blood clot; used in treating acute myocardial infarction

Activase

clot buster, thrombolytic, thrombolytic agent - a kind of pharmaceutical that can break up clots blocking the flow of blood to the heart muscle

Translations

tissue plasminogen activator (tPA)

n activador m tisular del plasminógeno, activador del plasminógeno tisular

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References in periodicals archive

Tissue plasminogen activator, Somatostatin, DNA vaccine, Growth, Lactation.

Construction and Evaluation of Novel Plasmid DNA Encoding Somatostatin Fused to a Tissue Plasminogen Activator (tPA) in Mice

Although the abbreviations "tPA," "TPA," or rt-PA" are often used when referring to alteplase, they are also used when referencing the larger class of recombinant tissue plasminogen activator medications.

Leading the Way by Adopting Safe Medication Practices Associated With Abbreviation Use

Injection of tissue plasminogen activator into a branch retinal vein in eyes with central retinal vein occlusion.

EFFECTIVENESS OF RADIAL OPTIC NEUROTOMY FOR ISCHEMIC CENTRAL RETINAL VEIN OCCLUSION

Tissue plasminogen activator for acute ischemic stroke.

Efficiency of Intravenous Thrombolytic Therapy in Isolated Middle Cerebral Artery Occlusions: A Computed Tomography Angiography Study/Izole Orta Serebral Arter Okluzyonlarinda Intravenoz Trombolitik Tedavinin Yeri: Bilgisayarli Tomografi Anjiyografi Calismasi

Though limited by a smaller number of postimplementation cases and lack of 3-month poststroke functional outcome data, the findings suggest that 24/7 in-hospital availability of a neurologist improves door to intravenous tissue plasminogen activator treatment times and in-hospital stroke mortality, Dr.

24/7 neurologist coverage improved stroke survival

Intravenous thrombolysis with recombinant tissue plasminogen activator for acute hemispheric stroke.

The association between t-PA administration and in-hospital mortality following acute ischemic stroke in Puerto Rican patients

'Alteplase, or tissue plasminogen activator, is ideally given in the first three hours upon onset of acute stroke,' Tayag said at a press briefing, stressing that only patients who have an ischemic type of stroke, or those with blocked blood vessels in the brain, will benefit from the medicine since alteplase breaks down unwanted blood clots.

Free medicine available for stroke victims-DOH

Known as tissue plasminogen activator (tPA), it is already available in neighbouring countries, but concerns over its safety and logistics have delayed its use in Bahrain.

Lifeline for Bahrain stroke patients

In the case of a mild stroke, doctors are often reluctant to administer tissue plasminogen activator (tPA), a drug that helps dissolve blood clots.

Revascularization after a mild stroke may benefit patients: Cleveland Clinic study suggests that a less-conservative approach to treating mild ischemic stroke patients may reduce the risks of further complications

To receive the Target: Stroke Honor Roll-Elite award, South Nassau fulfilled quality measures developed to reduce the time between the patient's arrival at the hospital and treatment with the clot-buster tissue plasminogen activator, or tPA, the only drug approved by the U.S.

South Nassau Communities Hospital is Among the Elite at Treating Stroke