Tivozanib is an oral, once-daily, potent and highly-selective
vascular endothelial growth factor receptor tyrosine kinase inhibitor.
TGFB1 induces the
vascular endothelial growth factor expression (34, 43).
Key Words: Moderate exercise,
Vascular endothelial growth factor, Wound healing, Wistar rats
* Replenishing four growth factors--epidermal growth factor (EGF), insulin-like growth factor-1 (IGF-1),
vascular endothelial growth factor (VEGF), fibroblast growth factor (FGF)--through topical application has been shown to diminish wrinkles, improve elasticity, and restore moisture to rejuvenate aging skin.
Chang et al., "Vascular dysfunction induced by elevated glucose levels in rats is mediated by
vascular endothelial growth factor," Journal of Clinical Investigation, vol.
IL-1 gene expression, chemokines, adhesion molecules, transforming growth factor-[beta]1, and
vascular endothelial growth factor also significantly increased compared with IL-6-deficient BALB/c mice [14].
Jabbour, "Expression and regulation of the prokineticins (endocrine gland-derived
vascular endothelial growth factor and Bv8) and their receptors in the human endometrium across the menstrual cycle," The Journal of Clinical Endocrinology and Metabolism, vol.
Sage, "Regulation of retinal capillary cells by basic fibroblast growth factor,
vascular endothelial growth factor, and hypoxia," In Vitro Cellular & Developmental Biology.
To promote proliferation of malignant tumors, factors related to angiogenesis such as
vascular endothelial growth factor (VEGF) and cluster of differentiation 34 (CD34) are always overexpressed.
In angiogenesis, several cytokines play important roles, but the
vascular endothelial growth factor (VEGF) is considered to be vital (Arras et al., 1998).