Similar to the
vinca alkaloids and taxanes, 6.02 is now a fully synthesized therapeutic, originally derived from naturally occurring compounds.
Born on September 23, 1917, Dr Asima Chatterjee has various contributions on the research of
vinca alkaloids and the development of anti-epileptic and anti-malarial drugs.
Vinca alkaloids cause aberrant ROS-mediated JNK activation, Mcl-1 downregulation, DNA damage, mitochondrial dysfunction, and apoptosis in lung adenocarcinoma cells.
APP-111 is a platform technology that may have activity in other tumor types that have previously responded to taxanes or
vinca alkaloids.
Pharmacokinetic drug interactions of
vinca alkaloids: summary of case reports.
These include the taxanes (paclitaxel, docetaxel) and the
vinca alkaloids (vincristine, vinblastine).