A semisynthetic penicillin, C19H17Cl2N3O5S, that is resistant to penicillinase, used in the form of its sodium salt primarily to treat infections caused by penicillinase-producing staphylococcus bacteria.
Initially diagnosed as impetigo, empiric treatment with sulfamethoxazole/trimethoprim (800 mg/I60 mg PO BID for 7 days), dicloxacillin (500 mg PO BID for 6 days), cephalexin (500 mg TID for 5 days), and mupirocin (2% topical cream applied TID for 6 days) failed to improve the patient's symptoms.
Depending on culture and susceptibility data, alternative agents such as doxycycline, minocycline, erythromycin, cephalexin, or dicloxacillin can be used.[17],[27]
He completed a 6-week course of IV flucloxacillin, followed by a 6-week course of oral dicloxacillin, and remained clinically well throughout this time.
The patient completed six weeks of intravenous oxacillin and was later started on suppressive antibiotic therapy with oral dicloxacillin 500 mg twice daily given the fact that he had high disease burden and had not undergone surgical intervention.
The standard of lincomycin, from the lincosamides family, as well as the standards from the macrolides (clindamycin, erythromycin, spiramycin, tilmicosin, and tylosin) and [beta]-lactams (cefazolin, cloxacillin, dicloxacillin, oxacillin, nafcillin, penicillin G, and penicillin V) families were purchased from Sigma Chemical Co.
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