An alkaloid, C46H56N4O10, originally obtained from the Madagascar periwinkle and used in its sulfate form to treat acute leukemia and a variety of other neoplasms.
[New Latin Vinca, periwinkle genus; see vinca + Latin crista, crest; see crest + -ine.]
Regimen-A included three drugs (dexamethasone, vincristine and asparaginase) and Regimen-B included four drugs (dexa-methasone, vincristine, asparaginase and daunorubicin) Remission status was assessed after 1 month of induction chemotherapy by blood complete counts and bone marrow examination.
In 2016, Hataet al.,retrospectively analyzed the long-term outcome of a case series (36 patients) with OD treated with RTand procarbazine, nimustine, vincristine (PAV) therapy.3 Their results showed that IDH mutation and 1p/19q loss were the prognostic factors to consider for OD, not WHO grade, furthermore there was a significantly better prognosis for patients with 1p/19q co-deletion.
In our centre, adolescent and adult ES patients (age > 16 years) with localized and metastatic disease have been treated between 1990 and 2014 with two alternating chemotherapy regimens: VIA (vincristine, ifosfamide, and doxorubicin) and VIP (etoposide, ifosfamide, and cisplatin).
[11] Published treatment guidelines for the management of KS in resource-limited settings include chemotherapy with the single drugs etoposide, thalidomide and vincristine, with two drugs, namely vincristine and bleomycin, and with three drugs, namely doxorubicin (Adriamycin), bleomycin and vinblastine sulphate.
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