WEDNESDAY, July 17, 2019 (HealthDay News) -- In patients with
membranous nephropathy at high risk for progressive disease, rituximab is noninferior to cyclosporine in inducing complete or partial remission of proteinuria at 12 months and is superior in maintaining proteinuria remission up to 24 months, according to a study published in the July 4 issue of the New England Journal of Medicine.
In the middle-aged group, the two most common pathological patterns were IgAN and
membranous nephropathy.
Membranous nephropathy was the most common pathological pattern in elderly patients with NDRD, accounting for 29.3%.
Apellis is currently conducting a Phase 2 trial of APL-2 in four types of glomerular diseases in which complement has been implicated: C3 glomerulopathy, IgA nephropathy, primary
membranous nephropathy and lupus nephritis.
Several associations between autoimmune hepatitis, and polymyositis/dermatomyositis with other diseases have been documented: with thyroiditis and antiphospholipid syndrome; systemic sclerosis and cerebral vasculitis; primary biliary cirrhosis and thrombocytopenic purpura; myasthenia gravis and thymoma;
membranous nephropathy and Sjogren's syndrome; and, finally, with systemic sclerosis and sarcoidosis of mediastinal lymphoid nodules (3-8).
Thrombotic complications in childhood-onset idiopathic
membranous nephropathy. Pediatr Nephrol 2003;18(12):1298-300.
Upon resolution of HZ, a second biopsy was performed with findings of thickened capillary walls with lucencies, moderate mesangial matrix expansion, and no podocytes abnormality on the light microscopy (LM) (Figure 1), and negative immunofluorescent study (IF) for IgG, IgA, C3, C1q, light chains, and faint IgM on IF, and electronmicroscopy (EM) with complete (90-100%) effacement of foot processes, acellular debris in thickened capillary walls, and sparse immune deposits in mesangium (Figure 2), which were consistent with healed
membranous nephropathy (MN) and minimal change disease- (MCD-) like process.
The most common type of GN was lupus nephritis (33.5%), followed by
membranous nephropathy (15.3%), and diabetic nephropathy (11.0%); the least common types of GN were Alport syndrome with an incidence of less than 1% and amyloidosis, crescentic GN, and postinfectious GN with an incidence of 4 (1.9%) each (Table 1, Figure 1).
The subjects included patients with FSGS, MCNS,
membranous nephropathy, renal amyloidosis, lupus nephritis, membranoproliferative glomerulonephritis, and crescentic glomerulonephritis.