Thus, it appears that daunomycin can induce a wide array of
mutational events which include frameshifts and base-substitution mutations.
The nature of radon/radon daughter-induced
mutational lesions in human lymphoblasts is also investigated.
Numerous studies in a wide array of species have revealed that the
mutational rate of production of new variation for morphological, behavioral, and life-history traits is sufficient to increase heritabilities by approximately 0.1 to 1.0 percent per generation (see reviews in Lande 1976; Lynch 1988; Houle et al.
A second thrust explores the limitations of natural selection as a mechanism for generating order and fitness, showing how evolving systems can get sidetracked by
mutational drift, internal complexity, and myopic adherence to local rather than global optima.
Bio-Techne announced the publication of a recent validation study demonstrating that the proprietary exosome-based liquid biopsy tests from Bio-Techne's Exosome Diagnostics brand may be used to assess the
mutational status of the Epidermal Growth Factor Receptor - or EGFR - gene in patients with non-small cell lung cancer.
NEC and Transgene have capitalised on the recent progress in AI and advances in genome sequencing to create individualized immunotherapy, which is adapted to the unique characteristics of each patient's
mutational landscape as well as their predicted immune responses.
ThyGeNEXT is a next generation
mutational panel for indeterminate thyroid nodules.
MONDAY, April 16, 2018 (HealthDay News) -- For metastatic non-small-cell lung cancer (NSCLC), the addition of pembrolizumab to standard chemotherapy is beneficial; and nivolumab plus ipilimumab is associated with better survival than chemotherapy for NSCLC with high tumor
mutational burden, according to two studies published online April 16 in the New England Journal of Medicine to coincide with the annual meeting of the American Association for Cancer Research, held from April 14 to 18 in Chicago.
It is known to be resistant to conventional chemotherapy, and although DM tumors typically have high
mutational loads, they generally lack driver mutations that could be treated with targeted agents, the investigators noted.
The major implication of this research, they say, is that many of the tumor specific changes in DNA or histone methylation that might have been previously interpreted as epigenetic phenomena, are in fact the direct consequences of
mutational changes in genes that encode chromatin regulators.
A: BRAF
Mutational Analysis.--BRAF mutations occur in up to 50% of melanomas.