sul·fo·nyl·u·re·a

(sŭl′fə-nĭl-yo͝o-rē′ə)

Any of a group of hypoglycemic drugs, such as glyburide, that act on the beta cells of the pancreas to increase the secretion of insulin and are used in the treatment of type 2 diabetes.

American Heritage® Dictionary of the English Language, Fifth Edition. Copyright © 2016 by Houghton Mifflin Harcourt Publishing Company. Published by Houghton Mifflin Harcourt Publishing Company. All rights reserved.

ThesaurusAntonymsRelated WordsSynonymsLegend:

Noun

sulfonylurea - antidiabetic consisting of any of several drugs that reduce the level of glucose in the blood; used to treat diabetes mellitus

antidiabetic, antidiabetic drug - a drug used to treat diabetes mellitus

tolazamide, Tolinase - a drug (trade name Tolinase) used in treating stable adult-onset diabetes mellitus

Orinase, tolbutamide - sulfonylurea; an oral antidiabetic drug (trade name Orinase) used in the treatment of adult-onset diabetes mellitus

Translations

sulfonylurea

n sulfonilurea

Mentioned in

References in periodicals archive

WEDNESDAY, July 24, 2019 (HealthDay News) -- Metformin use is associated with a substantially lower risk for dementia among younger African-American patients with diabetes compared with sulfonylurea initiation, according to a study published in the July/August issue of the Annals of Family Medicine.

Metformin May Lower Dementia Risk in Black Patients With T2DM; Findings strongest in younger African-American patients aged 50 to 64 years

Metformin is known to reduce TSH (thyroid stimulating hormone) levels, and this property may be beneficial in refractory hypothyroid patients with concomitant diabetes.8 Older sulfonylureas exhibit a goitrogenic effect, and inhibit the synthesis of thyroid hormone.9 Pioglitazone can cause orbital oedema by increasing IGF1 (insulin like growth factor-1), adipose tissue synthesis and TSH secretion.10 There are reports of increased risk of thyroid malignancy with older sulfonylurea and certain insulin analogues, but these are not substantiated and do not impact modern clinical practice.11,12 Liraglutide is contraindicated in persons with medullary thyroid carcinoma.13

Thyrovigilance in diabetes; glucovigilance in thyroidology

Sulfonylurea is the treatment of choice in patients with KCNJ11 or ABCC8 mutations (13,25).

A Novel KCNJ11 Mutation Associated with Transient Neonatal Diabetes

The channel contains a regulatory subunit, composed of the ABCC8 or ABCC9 (ATP-binding cassette, subfamily C members 8 and 9) gene products referred to as sulfonylurea receptor 1 and 2 (SUR1 and SUR2) proteins [2], respectively.

Glimepiride Administered in Chow Reversibly Impairs Glucose Tolerance in Mice

The label was also updated to include results from the AWARD-8 clinical trial, a Phase 3b randomized, double-blind, placebo-controlled, 24-week study that evaluated the efficacy and safety of Trulicity 1.5mg as an add-on to sulfonylurea compared to placebo plus sulfonylurea.

Eli Lilly has Trulicity label updated

Consider a dipeptidyl peptidase-4 inhibitor before a sulfonylurea for patients with type 2 diabetes mellitus who require therapy in addition to metformin.

Need an add-on to metformin? Consider this: sulfonylureas have been the preferred add-on therapy to metformin for T2DM; but a study finds that DPP-4s have lower risks of death, CV events, and hypoglycemia

If the patient is taking a sulfonylurea or insulin, the dose may need to be reduced when an SGLT-2 is initiated to avoid hypoglycemia.

Multipronged approach needed for diabetes

Patients with type 2 diabetes mellitus treated with metformin as a monotherapy are at a decreased risk for cardiovascular mortality when compared with those on sulfonylurea monotherapy.

Analysis confirms metformin as first line in 2DM

Patients with type 2 diabetes treated with metformin as a monotherapy are at a decreased risk for cardiovascular mortality, compared with those on sulfonylurea monotherapy, according to a report in the Annals of Internal Medicine.

New analysis bolsters metformin as first-line treatment in diabetes

Police said, on a tip-off, police raided Sulfonylurea factory located at Chowk Azam and arrested the owner and four others.

Layyah toxic sweets